『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=372053)

EID=372053EID:372053, Map:0, LastModified:2020年10月30日(金) 19:29:31, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[常山 幸一], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Zhang W (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Moritoki Y (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Yang G-X (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Ilan Y (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Lian Z-X (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Gershwin M E (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Beta-glucosylceramide ameliorates liver inflammation in murine autoimmune cholangitis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have demonstrated spontaneous development of autoimmune cholangitis, similar to human primary biliary cirrhosis, in mice expressing a dominant negative form of the transforming growth factor-beta receptor (dnTGF-betaRII) restricted to T cells. The autoimmune cholangitis appears to be mediated by autoreactive CD8(+) T lymphocytes that home to the portal tracts and biliary system. Because the liver pathology is primarily secondary to CD8(+) T cells, we have determined herein whether administration of beta-glucosylceramide (GC), a naturally occurring plant glycosphingolipid, alters the natural history of disease in this model. We chose GC because previous work has demonstrated its ability to alter CD8(+) T cell responses and to down-regulate tissue inflammation. Accordingly, dnTGF-betaRII mice were treated with either GC or control for a period of 18 weeks beginning at 6 weeks of age. Importantly, in mice that received GC, there was a significant decrease in the frequency and absolute number of autoreactive liver-infiltrating CD8(+) T cells, accompanied by a significant decrease in activated CD44(high) CD8(+) T cell populations. Further, there was a significant reduction in portal inflammation in GC-treated mice. Interestingly, there were no changes in anti-mitochondrial antibodies, CD4(+) T cells, CD19(+) B cells or natural killer (NK) T cell populations, indicating further that the beneficial effects of GC on liver inflammation were targeted specifically to liver-infiltrating CD8(+) T cells. These data suggest that further work on GC in models of CD8(+) T-mediated inflammation are needed and point to a new therapeutic venue for potentially treating and/or modulating autoimmune disease.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Autoimmune Diseases (日) (読) [継承]
3. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
4. (英) Cholangitis (日) (読) [継承]
5. (英) Flow Cytometry (日) (読) [継承]
6. (英) Glucosylceramides (日) (読) [継承]
7. (英) Liver (日) (読) [継承]
8. (英) Liver Cirrhosis, Biliary (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Transgenic (日) (読) [継承]
11. (英) Models, Animal (日) (読) [継承]
12. (英) Protein-Serine-Threonine Kinases (日) (読) [継承]
13. (英) Receptor, Transforming Growth Factor-beta Type II (日) (読) [継承]
14. (英) Receptors, Transforming Growth Factor beta (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 1365-2249
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 157 [継承]
(必須): 3 [継承]
(必須): 359 364 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 9月 初日 (平成 21年 9月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2249.2009.03971.x    (→Scopusで検索) [継承]
PMID (任意): 19664143    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]
2.(英) PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
3.(英) PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● W Zhang, Y Moritoki, Koichi Tsuneyama, G-X Yang, Y Ilan, Z-X Lian and E M Gershwin : Beta-glucosylceramide ameliorates liver inflammation in murine autoimmune cholangitis., Clinical and Experimental Immunology, Vol.157, No.3, 359-364, 2009.
欧文冊子 ● W Zhang, Y Moritoki, Koichi Tsuneyama, G-X Yang, Y Ilan, Z-X Lian and E M Gershwin : Beta-glucosylceramide ameliorates liver inflammation in murine autoimmune cholangitis., Clinical and Experimental Immunology, Vol.157, No.3, 359-364, 2009.

関連情報

Number of session users = 2, LA = 1.77, Max(EID) = 383290, Max(EOID) = 1024441.