『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=371165EID:371165, Map:0, LastModified:2020年9月7日(月) 10:48:36, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[姚 陳娟], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Liu Yingqi (日) (読)
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[継承]
2. (英) Wei Haiyan (日) (読)
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[継承]
3. (英) Tang Jing (日) (読)
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[継承]
4. (英) Yuan Jiaming (日) (読)
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[継承]
5. (英) Wu Mingmin (日) (読)
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[継承]
6.姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
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[継承]
7.細井 和雄
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[継承]
8. (英) Yu Shali (日) (読)
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[継承]
9. (英) Zhao Xinyuan (日) (読)
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[継承]
10. (英) Han Yu (日) (読)
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[継承]
11. (英) Chen Gang (日) (読)
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[継承]
題名 (必須): (英) Dysfunction of pulmonary epithelial tight junction induced by silicon dioxide nanoparticles via the ROS/ERK pathway and protein degradation.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Silica nanoparticles (SiNPs) are one of the most widely used types of nanoparticles across many industrial sectors, and are known to be present in the air year-round. In this study, we aimed to evaluate the potential adverse effects of SiNP exposure on pulmonary epithelial tight junctions, which serve as a critical barrier between the respiratory system and the circulatory system. In vivo studies confirmed that SiNPs decreased the protein expression levels of zonula occludens 1 (ZO-1), zonula occludens 2 (ZO-2), and occludin in the lungs of C57BL/6 mice. In vitro studies showed that SiNPs not only decreased the mRNA and protein expression of ZO-1 and ZO-2, but also decreased the protein expression of occludin in human bronchial epithelial (BEAS-2B) cells. In addition, SiNP exposure increased reactive oxygen species (ROS) production and activated extracellular regulated protein kinases (ERKs) and c-Jun N-terminal kinase (JNK). The inhibition of ROS and ERKs effectively protected the SiNP-induced downregulation of ZO-1 mRNA and protein expression, but had no effect on ZO-2 or occludin expression. SiNP-induced matrix metalloproteinase 9 (MMP9) protein expression appeared to be involved in occludin proteolytic degradation, in addition to SiNP-induced direct occludin protein degradation. The present study suggests that SiNPs disturb pulmonary epithelial tight junction structure and function via the ROS/ERK pathway and protein degradation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Bronchi (日) (読) [継承]
3. (英) Down-Regulation (日) (読) [継承]
4. (英) Humans (日) (読) [継承]
5. (英) JNK Mitogen-Activated Protein Kinases (日) (読) [継承]
6. (英) Lung (日) (読) [継承]
7. (英) MAP Kinase Signaling System (日) (読) [継承]
8. (英) Mice (日) (読) [継承]
9. (英) Mice, Inbred C57BL (日) (読) [継承]
10.ナノ粒子 (nanoparticles/->キーワード[ナノ粒子]) [継承]
11. (英) Occludin (日) (読) [継承]
12. (英) Phosphoproteins (日) (読) [継承]
13. (英) Proteolysis (日) (読) [継承]
14.活性酸素 (reactive oxygen species/->キーワード[活性酸素種]) [継承]
15. (英) Silicon Dioxide (日) (読) [継承]
16. (英) Tight Junctions (日) (読) [継承]
17. (英) Zonula Occludens-1 Protein (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Chemosphere ([Elsevier])
(pISSN: 0045-6535, eISSN: 1879-1298)

ISSN (任意): 1879-1298
ISSN: 0045-6535 (pISSN: 0045-6535, eISSN: 1879-1298)
Title: Chemosphere
Title(ISO): Chemosphere
Publisher: Elsevier Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 255 [継承]
(必須):
(必須): 126954 126954 [継承]
都市 (任意):
年月日 (必須): 西暦 2020年 5月 3日 (令和 2年 5月 3日) [継承]
URL (任意):
DOI (任意): 10.1016/j.chemosphere.2020.126954    (→Scopusで検索) [継承]
PMID (任意): 32387908    (→Scopusで検索) [継承]
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WOS (任意):
Scopus (任意): 2-s2.0-85084223128 [継承]
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備考 (任意): 1.(英) Article.ELocationID: S0045-6535(20)31147-4  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/j.chemosphere.2020.126954  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: ERK  (日)    [継承]
5.(英) KeywordList.Keyword: Protein degradation  (日)    [継承]
6.(英) KeywordList.Keyword: ROS  (日)    [継承]
7.(英) KeywordList.Keyword: Silica nanoparticles  (日)    [継承]
8.(英) KeywordList.Keyword: Tight junctions  (日)    [継承]
9.(英) CoiStatement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.  (日)    [継承]

標準的な表示

和文冊子 ● Yingqi Liu, Haiyan Wei, Jing Tang, Jiaming Yuan, Mingmin Wu, Chenjuan Yao, Kazuo Hosoi, Shali Yu, Xinyuan Zhao, Yu Han and Gang Chen : Dysfunction of pulmonary epithelial tight junction induced by silicon dioxide nanoparticles via the ROS/ERK pathway and protein degradation., Chemosphere, Vol.255, (号), 126954, 2020.
欧文冊子 ● Yingqi Liu, Haiyan Wei, Jing Tang, Jiaming Yuan, Mingmin Wu, Chenjuan Yao, Kazuo Hosoi, Shali Yu, Xinyuan Zhao, Yu Han and Gang Chen : Dysfunction of pulmonary epithelial tight junction induced by silicon dioxide nanoparticles via the ROS/ERK pathway and protein degradation., Chemosphere, Vol.255, (号), 126954, 2020.

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