『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=370174)

EID=370174EID:370174, Map:0, LastModified:2020年8月25日(火) 10:52:58, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[漆原 真樹], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Shono Miki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.漆原 真樹 ([徳島大学.病院.診療科.小児·周産·女性科.小児科])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Suga Kenichi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Watanabe Noriko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Saijo Takahiko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.中川 竜二 ([徳島大学.病院.中央診療施設等.周産母子センター])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.香美 祥二 ([徳島大学.病院])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Enhanced angiotensinogen expression in neonates during kidney development.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We recently demonstrated that preterm neonates have higher urinary angiotensinogen (AGT) levels than full-term neonates. Here, we tested the hypothesis that enhanced neonatal AGT expression is associated with intrarenal renin-angiotensin system (RAS) status during kidney development. We prospectively recruited neonates born at our hospital and healthy children with minor glomerular abnormalities between April 2013 and March 2017. We measured neonatal plasma and urinary AGT levels at birth and 1 year later and assessed renal AGT expression in kidney tissues from neonates and healthy children using immunohistochemical (IHC) analysis. Fifty-four neonates and eight children were enrolled. Although there were no changes in plasma AGT levels, urinary AGT levels were significantly decreased 1 year after birth. Urinary AGT levels at birth were inversely correlated with gestational age, and urinary AGT levels at birth and 1 year later were inversely correlated with estimated glomerular filtration rate 1 year after birth. IHC analysis showed that renal AGT expression in neonates was higher than that in healthy children and inversely correlated with gestational age. Enhanced AGT expression and urinary AGT excretion may reflect intrarenal RAS activation associated with kidney development in utero.  (日)    [継承]
キーワード (推奨): 1. (英) Angiotensinogen (日) (読) [継承]
2. (英) Biopsy (日) (読) [継承]
3.子ども (children) [継承]
4. (英) Child, Preschool (日) (読) [継承]
5. (英) Creatinine (日) (読) [継承]
6.女性 (female) [継承]
7. (英) Gestational Age (日) (読) [継承]
8. (英) Glomerular Filtration Rate (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10.免疫組織化学 (immunohistochemistry) [継承]
11.小児 (infant) [継承]
12. (英) Infant, Newborn (日) (読) [継承]
13. (英) Kidney (日) (読) [継承]
14. (英) Kidney Glomerulus (日) (読) [継承]
15.男性 (male) [継承]
16. (英) Parturition (日) (読) [継承]
17. (英) Prospective Studies (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinical and Experimental Nephrology (日本腎臓学会)
(pISSN: 1342-1751, eISSN: 1437-7799)

ISSN (任意): 1437-7799
ISSN: 1342-1751 (pISSN: 1342-1751, eISSN: 1437-7799)
Title: Clinical and experimental nephrology
Title(ISO): Clin Exp Nephrol
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (医中誌Web  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 23 [継承]
(必須): 4 [継承]
(必須): 537 543 [継承]
都市 (任意):
年月日 (必須): 西暦 2019年 4月 1日 (平成 31年 4月 1日) [継承]
URL (任意):
DOI (任意): 10.1007/s10157-018-1662-3    (→Scopusで検索) [継承]
PMID (任意): 30353264    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-85055683646 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1007/s10157-018-1662-3  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: Angiotensinogen  (日)    [継承]
4.(英) KeywordList.Keyword: Kidney development  (日)    [継承]
5.(英) KeywordList.Keyword: Neonates  (日)    [継承]
6.(英) KeywordList.Keyword: Renin-angiotensin system  (日)    [継承]

標準的な表示

和文冊子 ● Miki Shono, Maki Urushihara, Kenichi Suga, Noriko Watanabe, Takahiko Saijo, Ryuji Nakagawa and Shoji Kagami : Enhanced angiotensinogen expression in neonates during kidney development., Clinical and Experimental Nephrology, Vol.23, No.4, 537-543, 2019.
欧文冊子 ● Miki Shono, Maki Urushihara, Kenichi Suga, Noriko Watanabe, Takahiko Saijo, Ryuji Nakagawa and Shoji Kagami : Enhanced angiotensinogen expression in neonates during kidney development., Clinical and Experimental Nephrology, Vol.23, No.4, 537-543, 2019.

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