| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Abe Shuichi (日) 阿部 秀一 (読) あべ しゅういち
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 佐藤 正大 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学]/[徳島大学.病院.診療科.内科.呼吸器・膠原病内科])
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| 3. | 青野 純典 ([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.先端医療創生科学講座.呼吸器・膠原病内科学])
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| 4. | 東 桃代 ([徳島大学.病院.中央診療施設等.感染制御部])
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| 5. | (英) Kishi Masami (日) 岸 昌美 (読)
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| 6. | (英) Kazuya Koyama (日) 小山 壱也 (読)
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| 7. | (英) Naoki Takahashi (日) 髙橋 直希 (読) たかはし なおき
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| ○学籍番号 (推奨): | □ | ****
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| 8. | 香川 耕造
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| ○学籍番号 (推奨): | □ | ****
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| 9. | 河野 弘 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域リウマチ・総合内科学])
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| 10. | 西岡 安彦 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.呼吸器・膠原病内科学])
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| ○題名 (必須): | □ | (英) Functional analysis of human fibrocytes derived from monocytes reveals their profibrotic phenotype through paracrine effects (日)
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| ○要約 (任意): | □ | (英) Fibrocytes, which are bone marrow-derived collagen-producing cells, were reported to play a role in the pathogenesis of pulmonary fibrosis. However, their function in pulmonary fibrosis is unclear. We analyzed their function compared with that of monocytes and localization in fibrotic tissues in patients with idiopathic pulmonary fibrosis (IPF). We compared the gene expression profile of monocyte-derived fibrocytes with that of monocytes by microarray analysis. Proliferation and differentiation into myofibroblasts were examined by 3H-thymidine incorporation assay and Western blotting. We measured the level of growth factors in the culture supernatant of fibrocytes by ELISA. The localization of fibrocytes in lung tissues of patients with IPF was determined by immunofluorescence staining. Compared with monocytes, fibrocytes had higher expression of extracellular matrix- and growth factor-encoding genes, including PDGF-B, FGF-2 and VEGF-B. Although fibrocytes did not proliferate in response to PDGF, co-culture of fibrocytes stimulated the growth of lung fibroblasts through the production of PDGF-BB. In the lung of IPF patients, CD45+Collagen-I+FSP-1+ cells, which have a similar phenotype to fibrocytes, were detected and co-stained with anti-PDGF antibody. This study suggested that fibrocytes function in pulmonary fibrosis partly by producing PDGF in the lungs of IPF patients. J. Med. Invest. 67 : 102-112, February, 2020. (日)
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| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: Tokushima Daigaku Igakubu (NLM Catalog)
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(医中誌Web)
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(Scopus)
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| ○巻 (必須): | □ | 67
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| ○号 (必須): | □ | 1.2
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| ○頁 (必須): | □ | 102 112
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2020年 2月 初日 (令和 2年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.67.102 (→Scopusで検索)
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| ○PMID (任意): | □ | 32378592 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.2152/jmi.67.102 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: PDGF (日)
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| 4. | (英) KeywordList.Keyword: fibroblast (日)
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| 5. | (英) KeywordList.Keyword: fibrocyte (日)
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| 6. | (英) KeywordList.Keyword: idiopathic pulmonary fibrosis (日)
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