| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Yamaguchi Tadashi (日) 山口 真司 (読) やまぐち ただし
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 宮本 健志 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| 3. | (英) Kitazato keiko (日) 北里 慶子 (読) きたざと けいこ
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| 4. | (英) Shikata Eiji (日) 四方 英二 (読) しかた えいじ
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| ○学籍番号 (推奨): | □ | ****
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| 5. | (英) Yamaguchi Izumi (日) 山口 泉 (読) やまぐち いづみ
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| ○学籍番号 (推奨): | □ | ****
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| 6. | 高麗 雅章 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| 7. | 島田 健司 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.脳·神経·精神科.脳神経外科])
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| 8. | 八木 謙次
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| 9. | 多田 恵曜 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| 10. | (英) Matsuzaki Yoshihito (日) 松崎 慶仁 (読) まつざき よしひと
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| ○学籍番号 (推奨): | □ | ****
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| 11. | 兼松 康久
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| 12. | 髙木 康志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| ○題名 (必須): | □ | (英) Time-dependent and site-dependent morphological changes in rupture-prone arteries: ovariectomized rat intracranial aneurysm model (日)
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| ○要約 (任意): | □ | (英) The pathogenesis of intracranial aneurysm rupture remains unclear. Because it is difficult to study the time course of human aneurysms and most unruptured aneurysms are stable, animal models are used to investigate the characteristics of intracranial aneurysms. The authors have newly established a rat intracranial aneurysm rupture model that features site-specific ruptured and unruptured aneurysms. In the present study the authors examined the time course of changes in the vascular morphology to clarify the mechanisms leading to rupture. Ten-week-old female Sprague-Dawley rats were subjected to hemodynamic changes, hypertension, and ovariectomy. Morphological changes in rupture-prone intracranial arteries were examined under a scanning electron microscope and the association with vascular degradation molecules was investigated. At 2-6 weeks after aneurysm induction, morphological changes and rupture were mainly observed at the posterior cerebral artery; at 7-12 weeks they were seen at the anterior Willis circle including the anterior communicating artery. No aneurysms at the anterior cerebral artery-olfactory artery bifurcation ruptured, suggesting that the inception of morphological changes is site dependent. On week 6, the messenger RNA level of matrix metalloproteinase-9, interleukin-1β, and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of metalloproteinase-2 was significantly higher at the posterior cerebral artery, but not at the anterior communicating artery, of rats with aneurysms than in sham-operated rats. These findings suggest that aneurysm rupture is attributable to significant morphological changes and an increase in degradation molecules. Time-dependent and site-dependent morphological changes and the level of degradation molecules may be indicative of the vulnerability of aneurysms to rupture. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Neurosurgery (American Association of Neurological Surgeons/Harvey Cushing Society)
(pISSN: 0022-3085, eISSN: 1933-0693)
| ○ISSN (任意): | □ | 1933-0693
ISSN: 0022-3085
(pISSN: 0022-3085, eISSN: 1933-0693) Title: Journal of neurosurgeryTitle(ISO): J NeurosurgPublisher: American Association of Neurological Surgeons (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ |
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ |
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2019年 9月 13日 (令和 元年 9月 13日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3171/2019.6.JNS19777 (→Scopusで検索)
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| ○PMID (任意): | □ | 31518986 (→Scopusで検索)
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): | 1. | 髙木 康志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.脳神経外科学])
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.3171/2019.6.JNS19777 (日)
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| 2. | (英) Article.ELocationID: 2019.6.JNS19777 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: ACA-OlfA = anterior cerebral artery-olfactory artery (日)
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| 5. | (英) KeywordList.Keyword: ACoA = anterior communicating artery (日)
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| 6. | (英) KeywordList.Keyword: GAPDH = glyceraldehyde-3-phosphate dehydrogenase (日)
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| 7. | (英) KeywordList.Keyword: IL-1β = interleukin-1β (日)
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| 8. | (英) KeywordList.Keyword: MMP-9 = matrix metalloproteinase-9 (日)
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| 9. | (英) KeywordList.Keyword: OVX = ovariectomy (日)
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| 10. | (英) KeywordList.Keyword: PCA = posterior cerebral artery (日)
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| 11. | (英) KeywordList.Keyword: SAH = subarachnoid hemorrhage (日)
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| 12. | (英) KeywordList.Keyword: SEM = scanning electron microscope (日)
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| 13. | (英) KeywordList.Keyword: TIMP2 = tissue inhibitor of metalloproteinase-2 (日)
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| 14. | (英) KeywordList.Keyword: animal models (日)
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| 15. | (英) KeywordList.Keyword: degradation molecules (日)
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| 16. | (英) KeywordList.Keyword: intracranial aneurysm (日)
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| 17. | (英) KeywordList.Keyword: mRNA = messenger RNA (日)
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| 18. | (英) KeywordList.Keyword: morphology (日)
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| 19. | (英) KeywordList.Keyword: qRT-PCR = quantitative reverse transcription polymerase chain reaction (日)
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| 20. | (英) KeywordList.Keyword: subarachnoid hemorrhage (日)
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| 21. | (英) KeywordList.Keyword: vascular disorders (日)
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