『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=363778)

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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Goto Yuriko (日) (読)
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[継承]
2. (英) Ibi Miho (日) (読)
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[継承]
3. (英) Sato Hirotaka (日) (読)
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[継承]
4. (英) Tanaka Junichi (日) (読)
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5. (英) Yasuhara Rika (日) (読)
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6.青田 桂子 ([徳島大学.病院.診療科.歯科口腔外科.口腔内科])
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7.東 雅之
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8. (英) Fukada Toshiyuki (日) (読)
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9. (英) Mishima Kenji (日) (読)
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10. (英) Irie Tarou (日) (読)
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題名 (必須): (英) PLAG1 enhances the stemness profiles of acinar cells in normal human salivary glands in a cell type-specific manner.  (日)    [継承]
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要約 (任意): (英) Details of the histogenesis of salivary gland tumors are largely unknown. The oncogenic role of PLAG1 in the salivary gland has been demonstrated in vivo. Herein, we demonstrate PLAG1 roles in the acinar and ductal cells of normal human salivary glands to clarify the early events that occur during the histogenesis of salivary gland tumors. Normal salivary gland cells with acinar and ductal phenotypes were transfected with PLAG1 plasmid DNA. Subsequently, PLAG1 overexpressed and mock cells were examined by cell proliferation, transwell migration, and salisphere formation assays. Differentiation and salivary and pluripotent stem cell marker expression levels were evaluated by quantitative reverse transcription-polymerase chain reaction and immunofluorescence. Alterations in transcriptional expressions were investigated via cap analysis of gene expression with gene-enrichment and functional annotation analysis. PLAG1 promoted cell proliferation and transwell migration in the acinar and ductal cells, and markedly enhanced the stemness profiles and luminal cell-like profiles in acinar cells; the stemness profiles were partially increased in the ductal cells. PLAG1 enhanced the stemness profiles in the acinar cells of normal human salivary glands in a cell type-specific manner. Thus, it may be involved in salivary gland tumorigenesis by increasing the stemness character of the normal salivary gland cells.  (日)    [継承]
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誌名 (必須): Journal of Oral Biosciences ([歯科基礎医学会])
(pISSN: 1349-0079, eISSN: 1880-3865)

ISSN (任意): 1880-3865
ISSN: 1349-0079 (pISSN: 1349-0079, eISSN: 1880-3865)
Title: Journal of oral biosciences
Title(ISO): J Oral Biosci
Supplier: 歯科基礎医学会
Publisher: Japanese Association for Oral Biology
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 62 [継承]
(必須): 1 [継承]
(必須): 99 106 [継承]
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年月日 (必須): 西暦 2020年 1月 30日 (令和 2年 1月 30日) [継承]
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DOI (任意): 10.1016/j.job.2020.01.002    (→Scopusで検索) [継承]
PMID (任意): 32007659    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85079425125 [継承]
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備考 (任意): 1.(英) Article.ELocationID: S1349-0079(20)30002-5  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/j.job.2020.01.002  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: Acinar cell  (日)    [継承]
5.(英) KeywordList.Keyword: Pleomorphic adenoma gene 1  (日)    [継承]
6.(英) KeywordList.Keyword: Salivary gland neoplasm  (日)    [継承]
7.(英) KeywordList.Keyword: Stemness  (日)    [継承]
8.(英) KeywordList.Keyword: Tumorigenesis  (日)    [継承]

標準的な表示

和文冊子 ● Yuriko Goto, Miho Ibi, Hirotaka Sato, Junichi Tanaka, Rika Yasuhara, Keiko Aota, Masayuki Azuma, Toshiyuki Fukada, Kenji Mishima and Tarou Irie : PLAG1 enhances the stemness profiles of acinar cells in normal human salivary glands in a cell type-specific manner., Journal of Oral Biosciences, Vol.62, No.1, 99-106, 2020.
欧文冊子 ● Yuriko Goto, Miho Ibi, Hirotaka Sato, Junichi Tanaka, Rika Yasuhara, Keiko Aota, Masayuki Azuma, Toshiyuki Fukada, Kenji Mishima and Tarou Irie : PLAG1 enhances the stemness profiles of acinar cells in normal human salivary glands in a cell type-specific manner., Journal of Oral Biosciences, Vol.62, No.1, 99-106, 2020.

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