『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=362983)

EID=362983EID:362983, Map:0, LastModified:2022年3月31日(木) 14:56:06, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[大東 いずみ], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.近藤 博之 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨): **** [ユーザ]
[継承]
2. (英) Matsumura Takafumi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Kaneko Mari (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Inoue Kenichi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.小迫 英尊 ([徳島大学.先端酵素学研究所.基幹研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Ikawa Masahito (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.高浜 洋介
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.大東 いずみ ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) PITHD1 is a proteasome-interacting protein essential for male fertilization  (日)    [継承]
副題 (任意):
要約 (任意): (英) The proteasome is a protein-degrading molecular complex that is necessary for protein homeostasis and various biological functions, including cell cycle regulation, signal transduction, and immune response. Proteasome activity is finely regulated by a variety of proteasome-interacting molecules. PITHD1 is a recently described molecule that has a domain putatively capable of interacting with the proteasome. However, it is unknown whether PITHD1 can actually bind to proteasomes and what it does Here we report that PITHD1 is detected specifically in the spermatids in the testis and the cortical thymic epithelium in the thymus. Interestingly, PITHD1 associates with immunoproteasomes in the testis, but not with thymoproteasomes in the thymus. Mice deficient in PITHD1 exhibit severe male infertility accompanied with morphological abnormalities and impaired motility of spermatozoa. Furthermore, PITHD1 deficiency reduces proteasome activity in the testis and alters the amount of proteins that are important for fertilization capability by the sperm. However, the PITHD1-deficient mice demonstrate no detectable defects in the thymus, including T cell development. Collectively, our results identify PITHD1 as a proteasome-interacting protein that plays a nonredundant role in the male reproductive system.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): The Journal of Biological Chemistry ([The American Society for Biochemistry and Molecular Biology])
(pISSN: 0021-9258, eISSN: 1083-351X)

ISSN (任意): 1083-351X
ISSN: 0021-9258 (pISSN: 0021-9258, eISSN: 1083-351X)
Title: The Journal of biological chemistry
Title(ISO): J Biol Chem
Publisher: American Society for Biochemistry and Molecular Biology
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 295 [継承]
(必須): 6 [継承]
(必須): 1658 1672 [継承]
都市 (任意):
年月日 (必須): 西暦 2020年 2月 7日 (令和 2年 2月 7日) [継承]
URL (任意):
DOI (任意): 10.1074/jbc.RA119.011144    (→Scopusで検索) [継承]
PMID (任意): 31915251    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.ELocationID: 10.1074/jbc.RA119.011144  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: epithelial cell  (日)    [継承]
4.(英) KeywordList.Keyword: fertilization  (日)    [継承]
5.(英) KeywordList.Keyword: proteasome  (日)    [継承]
6.(英) KeywordList.Keyword: sperm  (日)    [継承]
7.(英) KeywordList.Keyword: testis  (日)    [継承]
8.(英) KeywordList.Keyword: thymus  (日)    [継承]

標準的な表示

和文冊子 ● Hiroyuki Kondo, Takafumi Matsumura, Mari Kaneko, Kenichi Inoue, Hidetaka Kosako, Masahito Ikawa, Yousuke Takahama and Izumi Ohigashi : PITHD1 is a proteasome-interacting protein essential for male fertilization, The Journal of Biological Chemistry, Vol.295, No.6, 1658-1672, 2020.
欧文冊子 ● Hiroyuki Kondo, Takafumi Matsumura, Mari Kaneko, Kenichi Inoue, Hidetaka Kosako, Masahito Ikawa, Yousuke Takahama and Izumi Ohigashi : PITHD1 is a proteasome-interacting protein essential for male fertilization, The Journal of Biological Chemistry, Vol.295, No.6, 1658-1672, 2020.

関連情報

Number of session users = 0, LA = 0.38, Max(EID) = 405199, Max(EOID) = 1098800.