| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 和田 佑馬 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 2. | 髙田 厚史 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 3. | 池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 4. | 森根 裕二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | 居村 暁
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| 6. | 岩橋 衆一
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| 7. | 齋藤 裕 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 8. | 島田 光生
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| ○題名 (必須): | □ | (英) The protective effect of epigallocatechin 3-gallate on mouse pancreatic islets via the Nrf2 pathway. (日)
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| ○要約 (任意): | □ | (英) Epigallocatechin 3-gallate (EGCG), a green tea polyphenol, has been shown to have anti-oxidant and anti-inflammatory effects in vitro and in vivo. The aim of this study was to investigate the effects and mechanism of EGCG on isolated pancreatic islets as pre-conditioning for pancreatic islet transplantation. The pancreatic islets were divided into two groups: an islet culture medium group (control) and an islet culture medium with EGCG (100 M) group. We investigated the islet viability, Nrf2 expression, reactive oxygen species (ROS) production, and heme oxygenase-1 (HO-1) mRNA. Five hundred islet equivalents after 12 h of culture for the EGCG 100 M and control group were transplanted under the kidney capsule of streptozotocin-induced diabetic ICR mice. The cell viability and insulin secretion ability in the EGCG group were preserved, and the nuclear translocation of Nrf2 was increased in the EGCG group (p < 0.01). While the HO-1 mRNA levels were also higher in the EGCG group than in the control group (p < 0.05), the ROS production was lower (p < 0.01). An in vivo functional assessment showed that the blood glucose level had decreased in the EGCG group after transplantation (p < 0.01). EGCG protects the viability and function of islets by suppressing ROS production via the Nrf2 pathway. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Blood Glucose (日) (読)
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| 3. | カテキン (catechin)
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| 4. | (英) Cell Survival (日) (読)
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| 5. | 遺伝子発現 (gene expression)
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| 6. | (英) Heme Oxygenase-1 (日) (読)
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| 7. | (英) In Vitro Techniques (日) (読)
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| 8. | (英) Insulin Secretion (日) (読)
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| 9. | (英) Islets of Langerhans (日) (読)
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| 10. | (英) Islets of Langerhans Transplantation (日) (読)
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| 11. | 男性 (male)
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| 12. | (英) Mice, Inbred C57BL (日) (読)
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| 13. | (英) Mice, Inbred ICR (日) (読)
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| 14. | (英) NF-E2-Related Factor 2 (日) (読)
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| 15. | (英) RNA, Messenger (日) (読)
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| 16. | 活性酸素種 (reactive oxygen species)
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| 17. | (英) Tissue Culture Techniques (日) (読)
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| 18. | (英) Transplantation Conditioning (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Surgery Today ([社団法人 日本外科学会])
(pISSN: 0941-1291, eISSN: 1436-2813)
| ○ISSN (任意): | □ | 1436-2813
ISSN: 0941-1291
(pISSN: 0941-1291, eISSN: 1436-2813) Title: Surgery todayTitle(ISO): Surg TodaySupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 49
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 536 545
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2019年 2月 7日 (平成 31年 2月 7日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s00595-019-1761-0 (→Scopusで検索)
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| ○PMID (任意): | □ | 30730004 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s00595-019-1761-0 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Epigallocatechin 3-gallate (EGCG) (日)
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| 4. | (英) KeywordList.Keyword: Islet transplantation (日)
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| 5. | (英) KeywordList.Keyword: Nuclear factor erythroid 2-related factor 2 (Nrf2) (日)
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| 6. | (英) KeywordList.Keyword: Pre-conditioning (日)
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| 7. | (英) KeywordList.Keyword: Reactive oxygen species (ROS) production (日)
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