| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○著者 (必須): | 1. | 高石 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科麻酔科学]/[徳島大学.病院.診療科.歯科口腔外科.歯科麻酔科]/[徳島大学.歯学部.歯学科.口腔疾患系臨床歯学講座.歯科麻酔科学])
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| 2. | 北畑 洋
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| ○題名 (必須): | □ | (英) Electrons released from both flavins of NADPH-P450 reductase contribute to the reductive mobilization of iron from ferritin. (日)
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| ○要約 (任意): | □ | (英) Ferritin, an iron storage protein, plays an important role in iron homeostasis. The mechanism of reductive mobilization of iron from ferritin has not been clarified yet despite many studies. The aim of this study was to assess the mechanisms of the mobilization of iron from ferritin by NADPH P-450 reductase. Nucleotide-dependent flavoenzymes generated significant mobilization of iron from ferritin. The possibility of reductive mobilization of iron from ferritin by electrons released from flavin sites or heme site of two flavoenzymes was investigated to elucidate the mediator-independent mechanisms of such reductive mobilization. The mobilization by NADPH-P450 reductase in the presence of ferricyanide increased threefold, while in the presence of cytochrome C increased thirteen-fold. These results indicate that electrons released from both flavins of NADPH-P450 reductase contribute to the reductive mobilization of iron from ferritin. The mechanism of the mobilization of iron from ferritin is discussed. J. Med. Invest. 66 : 230-232, August, 2019. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 66
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| ○号 (必須): | □ | 3.4
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| ○頁 (必須): | □ | 230 232
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2019年 8月 初日 (令和 元年 8月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.66.230 (→Scopusで検索)
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| ○PMID (任意): | □ | 31656279 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.2152/jmi.66.230 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Electron (日)
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| 4. | (英) KeywordList.Keyword: Ferritin (日)
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| 5. | (英) KeywordList.Keyword: Flavoenzyme (日)
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| 6. | (英) KeywordList.Keyword: Iron (日)
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| 7. | (英) KeywordList.Keyword: Reductive mobilization (日)
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