| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士後期課程学生による研究報告
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Morito Katsuya (日) 森戸 克弥 (読) もりと かつや
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 2. | (英) Shimizu Ryota (日) 清水 良多 (読) しみず りょうた
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 3. | (英) Kitamura Nahoko (日) (読)
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| [継承] |
| 4. | (英) Park Si-Bum (日) (読)
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| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Kishino Shigenobu (日) (読)
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| [継承] |
| 6. | (英) Ogawa Jun (日) (読)
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| [継承] |
| 7. | 福田 達也
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| 8. | 小暮 健太朗 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
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| ○学籍番号 (推奨): |
| [継承] |
| 9. | 田中 保 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野])
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| ○題名 (必須): | □ | (英) Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Microorganisms in animal gut produce unusual fatty acids from the ingested diet. Two types of hydroxy fatty acids (HFAs), 10-hydroxy-cis-12-octadecenoic acid (HYA) and 10-hydroxy-octadecanoic acid (HYB), are linoleic acid (LA) metabolites produced by Lactobacillus plantarum. In this study, we investigated the metabolism of these HFAs in mammalian cells. When Chinese hamster ovary (CHO) cells were cultured with HYA, approximately 50% of the supplemented HYA disappeared from the dish within 24 h. On the other hand, the amount of HYA that disappeared from the dish of peroxisome (PEX)-deficient CHO cells was lower than 20%. Significant amounts of C2- and C4-chain-shortened metabolites of HYA were detected in culture medium of HYA-supplemented CHO cells, but not in medium of PEX-deficient cells. These results suggested that peroxisomal β-oxidation is involved in the disappearance of HYA. The PEX-dependent disappearance was observed in the experiment with HYB, but not with LA. We also found that HYA treatment up-regulates peroxisomal β-oxidation activity of human gastric MKN74 cells and intestinal Caco-2 cells. These results indicate a possibility that HFAs produced from gut bacteria affect lipid metabolism of host via modulation of peroxisomal β-oxidation activity. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids ([Elsevier Science])
(pISSN: 1388-1981, eISSN: 1879-2618)
| ○ISSN (任意): | □ | 1879-2618
ISSN: 1388-1981
(pISSN: 1388-1981, eISSN: 1879-2618) Title: Biochimica et biophysica acta. Molecular and cell biology of lipidsTitle(ISO): Biochim Biophys Acta Mol Cell Biol LipidsPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 1864
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| ○号 (必須): | □ | 11
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| ○頁 (必須): | □ | 1619 1628
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2019年 11月 初日 (令和 元年 11月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbalip.2019.07.010 (→Scopusで検索)
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| ○PMID (任意): | □ | 31351225 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S1388-1981(19)30130-1 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.bbalip.2019.07.010 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Fatty acid metabolism (日)
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| 5. | (英) KeywordList.Keyword: Gut lactic acid bacteria (日)
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| 6. | (英) KeywordList.Keyword: Hydroxy fatty acid (日)
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| 7. | (英) KeywordList.Keyword: Linoleic acid (日)
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| 8. | (英) KeywordList.Keyword: Peroxisomal β-oxidation (日)
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