『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Shetty Abhishek (日) (読)
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2. (英) Venkatesh Thejaswini (日) (読)
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3.堤 理恵 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.代謝栄養学])
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4. (英) Suresh Padmanaban S (日) (読)
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題名 (必須): (英) Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents.  (日)    [継承]
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要約 (任意): (英)   (日) The aim of this study was to evaluate whether Gemin 5, Cpeb, Xrn1, and Stau1 expression in rodent ovaries and uterine tissues is dependent on gonadotropins, steroid hormones, and leptin in the superovulation and ovariectomized mouse models of menopause. Treatment of pregnant mare serum gonadotropin-primed rats with human chorionic gonadotropin (hCG) significantly induced Stau1 and Gemin 5 messenger RNA expression in rat ovaries. Gemin 5 expression in ovaries was sustained at relatively high levels at 12 h and 24 h post hCG treatment compared to Stau1, suggesting its role in follicle development, ovulation, and luteogenesis in rat ovaries. Induced expression of Stau1 and Gemin 5 in the uterine tissue post hCG treatment at 12 h and 24 h-the duration between ovulation and post-ovulation-suggests their regulation by hCG and/or ovarian steroids, which are required for pregnancy establishment and maintenance. Cpeb expression was significantly higher (p < 0.05) in the uterine tissues after combined treatment of estradiol and leptin at 4 h. Further, the significant upregulation of uterine Gemin 5 and Xrn1 by the synergistic activities of leptin and estradiol at 40 h in ovariectomized mice establishes them as targets of cross-talk. Although these are preliminary data, the combination of Gemin 5, Cpeb, Xrn1, and Stau1 transcript alterations in rodent ovaries and uterine tissue displayed in two different experimental models underscore their importance as therapeutic targets for anovulation or in overcoming endometrial homeostasis disturbances during pregnancy due to obesity.   [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Chorionic Gonadotropin (日) (読) [継承]
3. (英) Cytoskeletal Proteins (日) (読) [継承]
4. (英) Estradiol (日) (読) [継承]
5. (英) Exoribonucleases (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Gene Expression Regulation (日) (読) [継承]
8. (英) Leptin (日) (読) [継承]
9. (英) Microtubule-Associated Proteins (日) (読) [継承]
10. (英) Ovariectomy (日) (読) [継承]
11. (英) Ovary (日) (読) [継承]
12. (英) Progesterone (日) (読) [継承]
13. (英) RNA-Binding Proteins (日) (読) [継承]
14. (英) Rats (日) (読) [継承]
15. (英) Rats, Wistar (日) (読) [継承]
16. (英) SMN Complex Proteins (日) (読) [継承]
17. (英) Superovulation (日) (読) [継承]
18. (英) Uterus (日) (読) [継承]
19. (英) mRNA Cleavage and Polyadenylation Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Molecular Biology Reports (Springer Netherlands)
(pISSN: 0301-4851, eISSN: 1573-4978)

ISSN (任意): 1573-4978
ISSN: 0301-4851 (pISSN: 0301-4851, eISSN: 1573-4978)
Title: Molecular biology reports
Title(ISO): Mol Biol Rep
Supplier: Kluwer Online
Publisher: Springer Nature
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(必須): 46 [継承]
(必須): 2 [継承]
(必須): 2533 2540 [継承]
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年月日 (必須): 西暦 2019年 1月 28日 (平成 31年 1月 28日) [継承]
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DOI (任意): 10.1007/s11033-019-04606-z    (→Scopusで検索) [継承]
PMID (任意): 30689188    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Abhishek Shetty, Thejaswini Venkatesh, Rie Tsutsumi and S Padmanaban Suresh : Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents., Molecular Biology Reports, Vol.46, No.2, 2533-2540, 2019.
欧文冊子 ● Abhishek Shetty, Thejaswini Venkatesh, Rie Tsutsumi and S Padmanaban Suresh : Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents., Molecular Biology Reports, Vol.46, No.2, 2533-2540, 2019.

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