| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Adachi K (日) (読)
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| ○学籍番号 (推奨): |
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| 2. | (英) Hashiguchi S (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | (英) Saito M (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | (英) Kashiwagi S (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | (英) Miyazaki T (日) (読)
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| 6. | (英) Kawai H (日) (読)
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| 7. | 山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 8. | (英) Iwase T (日) (読)
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| ○貢献度 (任意): |
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| 9. | 赤池 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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| 10. | 髙尾 正一郎 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.放射線科学系.医用画像解析学]/[徳島大学.医学部.保健学科.放射線技術科学専攻.診療放射線技術学講座])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 11. | (英) Kobayashi M (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | (英) Ishizaki M (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 13. | (英) Matsumura T (日) (読)
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| [継承] |
| 14. | (英) Mori-Yoshimura M (日) (読)
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| ○貢献度 (任意): |
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| [継承] |
| 15. | (英) Kimura E (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Detection and management of cardiomyopathy in female dystrophinopathy carriers (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Regular health checkups for mothers of patients with Duchenne muscular dystrophy have been performed at National Hospital Organization Tokushima Hospital since 1994. Among 43 mothers participated in this study, 28 dystrophinopathy carriers were identified. Skeletal and cardiac muscle functions of these subjects were examined. High serum creatine kinase was found in 23 subjects (82.1%). Obvious muscle weakness was present in 5 (17.8%) and had progressed from 1994 to 2015. Cardiomyopathy was observed in 15 subjects (60.0%), including dilated cardiomyopathy-like damage that was more common in the left ventricular (LV) posterior wall. Late gadolinium enhancement on cardiac MRI was found in 5 of 6 subjects, suggesting fibrotic cardiac muscle. In speckle tracking echocardiography performed seven years later, global longitudinal strain was decreased in these subjects, indicating LV myocardial contractile abnormality. These results suggest that female dystrophinopathy carriers should receive regular checkups for detection and treatment of cardiomyopathy, even if they have no cardiac symptoms. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Cardiomyopathies (日) (読)
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| 3. | (英) Contrast Media (日) (読)
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| 4. | (英) Creatine Kinase (日) (読)
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| 5. | (英) Disease Management (日) (読)
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| 6. | (英) Dystrophin (日) (読)
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| 7. | (英) Electrocardiography (日) (読)
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| 8. | (英) Female (日) (読)
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| 9. | (英) Gadolinium (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Image Processing, Computer-Assisted (日) (読)
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| 12. | (英) Middle Aged (日) (読)
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| 13. | (英) Muscle, Skeletal (日) (読)
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| 14. | (英) Mutation (日) (読)
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| 15. | (英) Natriuretic Peptide, Brain (日) (読)
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| 16. | (英) Neuroimaging (日) (読)
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| 17. | (英) Neurologic Examination (日) (読)
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| 18. | (英) Retrospective Studies (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of the Neurological Sciences (World Federation of Neurology)
(pISSN: 0022-510X, eISSN: 1878-5883)
| ○ISSN (任意): | □ | 1878-5883
ISSN: 0022-510X
(pISSN: 0022-510X, eISSN: 1878-5883) Title: Journal of the neurological sciencesTitle(ISO): J Neurol SciPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 386
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| ○号 (必須): |
| ○頁 (必須): | □ | 74 80
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 3月 15日 (平成 30年 3月 15日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.jns.2017.12.024 (→Scopusで検索)
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| ○PMID (任意): | □ | 29358000 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: S0022-510X(17)34515-X (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.jns.2017.12.024 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 5. | (英) KeywordList.Keyword: Cardiac magnetic resonance imaging (日)
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| 6. | (英) KeywordList.Keyword: Cardiomyopathy (日)
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| 7. | (英) KeywordList.Keyword: Female dystrophinopathy carrier (日)
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| 8. | (英) KeywordList.Keyword: Late gadolinium enhancement (日)
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| 9. | (英) KeywordList.Keyword: Speckle tracking echocardiography (日)
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