| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 黒田 雅士
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| ○学籍番号 (推奨): | □ | ****
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| 2. | (英) Tominaga Ayako (日) (読)
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| 3. | (英) Nakagawa Kasumi (日) (読)
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| 4. | (英) Nishiguchi Misa (日) (読)
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| 5. | (英) Sebe Mayu (日) (読)
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| 6. | (英) Miyatake Yumiko (日) (読)
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| 7. | (英) Kitamura Tadahiro (日) (読)
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| 8. | (英) Tsutsumi Rie (日) (読)
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| 9. | (英) Harada Nagakatsu (日) (読)
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| 10. | (英) Nakaya Yutaka (日) (読)
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| 11. | 阪上 浩
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| ○題名 (必須): | □ | (英) DNA Methylation Suppresses Leptin Gene in 3T3-L1 Adipocytes. (日)
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| ○要約 (任意): | □ | (英) Leptin is a key regulator of energy intake and expenditure. This peptide hormone is expressed in mouse white adipose tissue, but hardly expressed in 3T3-L1 adipocytes. Using bisulfite sequencing, we found that CpG islands in the leptin promoter are highly methylated in 3T3-L1cells. 5-azacytidine, an inhibitor of DNA methyltransferase, markedly increased leptin expression as pre-adipocytes matured into adipocytes. Remarkably, leptin expression was stimulated by insulin in adipocytes derived from precursor cells exposed to 5-azacytidine, but suppressed by thiazolidinedione and dexamethasone. In contrast, adipocytes derived from untreated precursor cells were unresponsive to both 5-azacytidine and hormonal stimuli, although lipid accumulation was sufficient to boost leptin expression in the absence of demethylation. Taken together, the results suggest that leptin expression in 3T3-L1 cells requires DNA demethylation prior to adipogenesis, transcriptional activation during adipogenesis, and lipid accumulation after adipogenesis. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)
| ○ISSN (任意): | □ | 1932-6203
ISSN: 1932-6203
(eISSN: 1932-6203) Title: PloS oneTitle(ISO): PLoS OnePublisher: PLOS (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 8
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| ○頁 (必須): | □ | e0160532 e0160532
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 8月 5日 (平成 28年 8月 5日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1371/journal.pone.0160532 (→Scopusで検索)
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| ○PMID (任意): | □ | 27494408 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1371/journal.pone.0160532 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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