| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Indalao L. I (日) (読)
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| ○学籍番号 (推奨): |
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| 2. | (英) Sawabuchi T (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | (英) Takahashi E (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) IL-1β is a key cytokine which induces trypsin upregulation in influenza virus-cutokine-trypsin cycle. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Severe influenza is characterized by a cytokine storm, and the influenza virus-cytokine-trypsin cycle is one of the important mechanisms of viral multiplication and multiple organ failure. The aim of this study was to define the key cytokine(s) responsible for trypsin upregulation. Mice were infected with influenza virus strain A/Puerto Rico/8/34 (H1N1) or treated individually or with a combination of interleukin-1β, interleukin-6, and tumor necrosis factor α. The levels of these cytokines and trypsin in the lungs were monitored. The neutralizing effects of anti-IL-1β antibodies on cytokine and trypsin expression in human A549 cells and lung inflammation in the infected mice were examined. Infection induced interleukin-1β, interleukin-6, tumor necrosis factor α, and ectopic trypsin in mouse lungs in a dose- and time-dependent manner. Intraperitoneal administration of interleukin-1β combined with other cytokines tended to upregulate trypsin and cytokine expression in the lungs, but the combination without interleukin-1β did not induce trypsin. In contrast, incubation of A549 cells with interleukin-1β alone induced both cytokines and trypsin, and anti-interleukin-1β antibody treatment abrogated these effects. Administration of the antibody in the infected mice reduced lung inflammation area. These findings suggest that IL-1β plays a key role in trypsin upregulation and has a pathological role in multiple organ failure. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cell Line (日) (読)
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| 3. | (英) Disease Models, Animal (日) (読)
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| 4. | (英) Epithelial Cells (日) (読)
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| 5. | 女性 (female)
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| 6. | (英) Host-Pathogen Interactions (日) (読)
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| 7. | (英) Humans (日) (読)
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| 8. | (英) Interleukin-1beta (日) (読)
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| 9. | (英) Interleukin-6 (日) (読)
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| 10. | (英) Lung (日) (読)
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| 11. | (英) Mice, Inbred C57BL (日) (読)
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| 12. | (英) Orthomyxoviridae (日) (読)
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| 13. | (英) Orthomyxoviridae Infections (日) (読)
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| 14. | トリプシン (trypsin)
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| 15. | (英) Tumor Necrosis Factor-alpha (日) (読)
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| 16. | (英) Up-Regulation (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Archives of Virology (International Union of Microbiological Societies)
(pISSN: 0304-8608, eISSN: 1432-8798)
| ○ISSN (任意): | □ | 1432-8798
ISSN: 0304-8608
(pISSN: 0304-8608, eISSN: 1432-8798) Title: Archives of virologyTitle(ISO): Arch VirolSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 162
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 201 211
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 10月 6日 (平成 28年 10月 6日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s00705-016-3093-3 (→Scopusで検索)
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| ○PMID (任意): | □ | 27714503 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-84990858678
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| ○researchmap (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s00705-016-3093-3 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) CoiStatement: Conflicts of Interest: None declared. (日)
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