| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究)
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Takeuchi, A (日) (読)
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| 2. | (英) Ozawa M (日) (読)
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| 3. | (英) Kanda Y (日) (読)
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| 4. | (英) Kozai M (日) (読)
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| 5. | 大東 いずみ ([徳島大学.先端酵素学研究所.重点研究部門])
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| 6. | (英) Kurosawa Y (日) (読)
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| 7. | (英) Rahman MA (日) (読)
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| 8. | (英) Kawamura T (日) (読)
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| 9. | (英) Shichida Y (日) (読)
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| 10. | (英) Umemoto E (日) (読)
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| 11. | (英) Miyasaka M (日) (読)
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| 12. | (英) Ludewig B (日) (読)
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| 13. | (英) Takahama Y (日) (読)
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| 14. | (英) Nagasawa T (日) (読)
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| 15. | (英) Katakai T (日) (読)
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| ○題名 (必須): | □ | (英) A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The spatiotemporal regulation of immune responses in the lymph node (LN) depends on its sophisticated tissue architecture, consisting of several subcompartments supported by distinct fibroblastic stromal cells (FSCs). However, the intricate details of stromal structures and associated FSC subsets are not fully understood. Using several gene reporter mice, we sought to discover unrecognized stromal structures and FSCs in the LN. The four previously identified FSC subsets in the cortex are clearly distinguished by the expression pattern of reporters including PDGFRβ, CCL21-ser, and CXCL12. Herein, we identified a unique FSC subset expressing both CCL21-ser and CXCL12 in the deep cortex periphery (DCP) that is characterized by preferential B cell localization. This subset was clearly different from CXCL12LepR FSCs in the medullary cord, which harbors plasma cells. B cell localization in the DCP was controlled chiefly by CCL21-ser and, to a lesser extent, CXCL12. Moreover, the optimal development of the DCP as well as medulla requires B cells. Together, our findings suggest the presence of a unique microenvironment in the cortex-medulla boundary and offer an advanced view of the multi-layered stromal framework constructed by distinct FSC subsets in the LN. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Frontiers in Immunology (Frontiers Research Foundation)
(eISSN: 1664-3224)
| ○ISSN (任意): | □ | 1664-3224
ISSN: 1664-3224
(eISSN: 1664-3224) Title: Frontiers in immunologyTitle(ISO): Front ImmunolPublisher: Frontiers Media SA (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 9
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 2196 2196
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 10月 2日 (平成 30年 10月 2日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3389/fimmu.2018.02196 (→Scopusで検索)
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| ○PMID (任意): | □ | 30333825 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85055079381
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.3389/fimmu.2018.02196 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) KeywordList.Keyword: chemokines (日)
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| 5. | (英) KeywordList.Keyword: deep cortex (日)
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| 6. | (英) KeywordList.Keyword: fibroblastic stromal cells (日)
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| 7. | (英) KeywordList.Keyword: lymph node (日)
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| 8. | (英) KeywordList.Keyword: medulla (日)
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| 9. | (英) KeywordList.Keyword: subcompartment (日)
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