| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 苛原 誠
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| 2. | (英) Shinahara Wakako (日) (読)
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| 3. | 杉本 真弓 ([徳島大学.病院.診療科.小児·周産·女性科.小児科])
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| 4. | (英) Ogawa Yukiko (日) (読)
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| 5. | (英) Shitsukawa Keiji (日) (読)
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| 6. | (英) Kubota Kenji (日) (読)
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| 7. | (英) Yang Limin (日) (読)
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| 8. | (英) Ohya Yukihiro (日) (読)
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| 9. | (英) Saito Hirohisa (日) (読)
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| ○貢献度 (任意): |
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| 10. | 香美 祥二 ([徳島大学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | 有澤 孝吉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.予防医学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 12. | 木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Trajectories of class-switching-related egg and cow's milk allergen-specific immunoglobulin isotype formation and its modification by eczema with low- and high-affinity immunoglobulin E during early infancy (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Allergen-specific immunoglobulin isotype formation associated with immunoglobulin class-switching during the lactation period is the immunological background for food allergy in infants. We analyzed the serial changes in the production of feeding type-related egg- and milk-specific immunoglobulin isotypes from birth to 6 months of age with or without eczema in 84 infants. Allergen-specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA, and IgE levels of hen's egg and bovine milk were measured in cord blood and blood samples from infants at 2, 4, and 6 months of age by the densely carboxylated protein microarray. Formula and mixed feeding were associated with a rapid increase in cow's milk allergen-specific immunoglobulins and feeding type-related significant differences in casein-specific immunoglobulin levels were detected. Breast and mixed feeding were associated with slow but significant increase in ovalbumin-specific IgG1 and IgE levels, but not other immunoglobulins. We found two different immunoglobulin isotype formation at 6 months of age with low- or high-affinity IgE against ovalbumin. One isotype formation pattern had relatively high ovalbumin-specific IgG1 levels, detectable IgG2, and low-affinity IgE, while the other had low ovalbumin-specific IgG1 levels, undetectable IgG2, and high levels of high-affinity IgE. The incidence of eczema was significantly higher in the latter pattern (84.6%), compared with the remaining infants (42.2%). Feeding practice-related allergen sensitization and immunoglobulin isotype formation were identified during the lactation period. The development of eczema during the lactation period could potentially modify the immunoglobulin isotype formation with high levels of high-affinity IgE. (日)
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| ○キーワード (推奨): | 1. | (英) Age Factors (日) (読)
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| 2. | (英) Allergens (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Antibody Affinity (日) (読)
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| 5. | (英) Antibody Formation (日) (読)
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| 6. | (英) Antibody Specificity (日) (読)
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| 7. | (英) Cattle (日) (読)
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| 8. | (英) Chickens (日) (読)
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| 9. | (英) Eczema (日) (読)
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| 10. | (英) Egg Hypersensitivity (日) (読)
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| 11. | (英) Eggs (日) (読)
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| 12. | 女性 (female)
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| 13. | (英) Humans (日) (読)
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| 14. | (英) Immunoglobulin Class Switching (日) (読)
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| 15. | (英) Immunoglobulin E (日) (読)
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| 16. | (英) Immunoglobulin Isotypes (日) (読)
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| 17. | 小児 (infant)
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| 18. | (英) Infant, Newborn (日) (読)
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| 19. | 男性 (male)
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| 20. | (英) Milk (日) (読)
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| 21. | (英) Milk Hypersensitivity (日) (読)
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| 22. | (英) Pregnancy (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Immunity, Inflammation and Disease ([John Wiley & Sons, Inc.])
(eISSN: 2050-4527)
| ○ISSN (任意): | □ | 2050-4527
ISSN: 2050-4527
(eISSN: 2050-4527) Title: Immunity, inflammation and diseaseTitle(ISO): Immun Inflamm DisPublisher: John Wiley and Sons Ltd (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 7
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 74 85
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2019年 6月 初日 (令和 元年 6月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/iid3.245 (→Scopusで検索)
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| ○PMID (任意): | □ | 30859748 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85062790988
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1002/iid3.245 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) KeywordList.Keyword: allergen microarray (日)
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| 5. | (英) KeywordList.Keyword: eczema (日)
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| 6. | (英) KeywordList.Keyword: food allergy (日)
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| 7. | (英) KeywordList.Keyword: high-affinity immunoglobulin E (日)
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| 8. | (英) KeywordList.Keyword: immunoglobulin isotype formation (日)
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| 9. | (英) KeywordList.Keyword: low-affinity immunoglobulin E (日)
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