『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=352146)

EID=352146EID:352146, Map:0, LastModified:2020年8月6日(木) 20:06:19, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[石田 竜弘], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
共著種別 (推奨): 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Mohamed M (日) (読)
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2. (英) Amr Selim Ahmed Ali Abu Lila (日) (読) あむる せりむ あはめど あり あぶ りら
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学籍番号 (推奨): **** [ユーザ]
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3.清水 太郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.総合薬学教育学系.総合薬学研究推進学])
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4. (英) Alaaeldin E (日) (読)
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[継承]
5. (英) Hussein A (日) (読)
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[継承]
6. (英) Sarhan H (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Szebeni J (日) (読)
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8.石田 竜弘 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.薬物動態制御学]/[徳島大学.大学院医歯薬学研究部.薬学域.連携研究部門(薬学域).寄附講座系(薬学域).がん細胞と代謝学]/[徳島大学.産業院])
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[継承]
題名 (必須): (英) PEGylated liposomes: immunological responses  (日)    [継承]
副題 (任意):
要約 (任意): (英) A commonly held view is that nanocarriers conjugated to polyethylene glycol (PEG) are non-immunogenic. However, many studies have reported that unexpected immune responses have occurred against PEG-conjugated nanocarriers. One unanticipated response is the rapid clearance of PEGylated nanocarriers upon repeat administration, called the accelerated blood clearance (ABC) phenomenon. ABC involves the production of antibodies toward nanocarrier components, including PEG, which reduces the safety and effectiveness of encapsulated therapeutic agents. Another immune response is the hypersensitivity or infusion reaction referred to as complement (C) activation-related pseudoallergy (CARPA). Such immunogenicity and adverse reactivities of PEGylated nanocarriers may be of potential concern for the clinical use of PEGylated therapeutics. Accordingly, screening of the immunogenicity and CARPA reactogenicity of nanocarrier-based therapeutics should be a prerequisite before they can proceed into clinical studies. This review presents PEGylated liposomes, immunogenicity of PEG, the ABC phenomenon, C activation and lipid-induced CARPA from a toxicological point of view, and also addresses the factors that influence these adverse interactions with the immune system.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): Science and Technology of Advanced Materials (IOP Publishing)
(pISSN: 1468-6996, eISSN: 1878-5514)

ISSN (任意): 1468-6996
ISSN: 1468-6996 (pISSN: 1468-6996, eISSN: 1878-5514)
Title: Science and technology of advanced materials
Title(ISO): Sci Technol Adv Mater
Publisher: Taylor & Francis
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 20 [継承]
(必須): 1 [継承]
(必須): 710 724 [継承]
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年月日 (必須): 西暦 2019年 6月 26日 (令和 元年 6月 26日) [継承]
URL (任意):
DOI (任意): 10.1080/14686996.2019.1627174    (→Scopusで検索) [継承]
PMID (任意): 31275462    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85068089055 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1080/14686996.2019.1627174  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
4.(英) KeywordList.Keyword: 101 Self-assembly / Self-organized materials, drug delivery system  (日)    [継承]
5.(英) KeywordList.Keyword: 30 Bio-inspired and biomedical materials  (日)    [継承]
6.(英) KeywordList.Keyword: Accelerated blood clearance (ABC) phenomenon  (日)    [継承]
7.(英) KeywordList.Keyword: PEGylated liposomes  (日)    [継承]
8.(英) KeywordList.Keyword: anti-PEG IgM  (日)    [継承]
9.(英) KeywordList.Keyword: complement activation  (日)    [継承]
10.(英) KeywordList.Keyword: complement activation-related pseudoallergy (CARPA)  (日)    [継承]
11.(英) KeywordList.Keyword: hypersensitivity reactions (HSRs)  (日)    [継承]
12.(英) KeywordList.Keyword: polyethylene glycol (PEG)  (日)    [継承]

標準的な表示

和文冊子 ● M Mohamed, Lila Selim Ahmed Ali Abu Amr, Taro Shimizu, E Alaaeldin, A Hussein, H Sarhan, J Szebeni and Tatsuhiro Ishida : PEGylated liposomes: immunological responses, Science and Technology of Advanced Materials, Vol.20, No.1, 710-724, June 2019.
欧文冊子 ● M Mohamed, Lila Selim Ahmed Ali Abu Amr, Taro Shimizu, E Alaaeldin, A Hussein, H Sarhan, J Szebeni and Tatsuhiro Ishida : PEGylated liposomes: immunological responses, Science and Technology of Advanced Materials, Vol.20, No.1, 710-724, June 2019.

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