『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=351807EID:351807, Map:0, LastModified:2019年5月17日(金) 12:39:10, Operator:[苛原 稔], Avail:TRUE, Censor:0, Owner:[苛原 稔], Read:継承, Write:継承, Delete:継承.
種別 (必須):
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.岩佐 武 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
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2.松崎 利也
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3.矢野 清人
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学籍番号 (推奨): **** [ユーザ]
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4. (英) Yiliyasi Mayila (日) Mayila Yiliyasi (読) まいら いりやす
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学籍番号 (推奨): **** [ユーザ]
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5.桑原 章
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6. (英) Matsui Sumika (日) (読)
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7.苛原 稔 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
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学籍番号 (推奨):
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題名 (必須): (英) Effects of chronic testosterone administration on the degree of preference for a high-fat diet and body weight in gonadal-intact and ovariectomized female rats.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Energy balance and reproductive functions are closely linked in some species. The sex hormones (estrogens and androgens) are involved in the regulation of appetite, metabolism, body weight (BW), and body composition in mammals. Previously, we showed that the effects of testosterone on BW, appetite, and fat weight were markedly affected by alterations to the gonadal hormonal milieu. In this study, we examined whether testosterone administration changes food preferences and whether these effects of testosterone depend on gonadal status in female rats. We also evaluated the underlying mechanisms responsible for these effects, focusing on hypothalamic inflammation and endoplasmic reticulum (ER) stress. In gonadal-intact (sham) female rats, chronic testosterone administration promoted a preference for a high-fat diet (HFD) and increased BW gain, fat weight, and adipocyte size, whereas no such effects were observed in ovariectomized (OVX) rats. Testosterone administration increased hypothalamic interleukin-1 mRNA expression in the sham rats, but not the OVX rats. On the contrary, testosterone administration decreased the hypothalamic mRNA levels of ER stress-response genes in the OVX rats, but not the sham rats. These testosterone-induced alterations in OVX rats might represent a regulatory mechanism for preventing hypothalamic inflammation and the overconsumption of a HFD. In conclusion, testosterone's effects on food preferences and the subsequent changes were affected by gonadal status. Testosterone-induced changes in hypothalamic inflammatory cytokine production and ER stress might be related to these findings.  (日)    [継承]
キーワード (推奨): 1. (英) Adipocytes (日) (読) [継承]
2. (英) Adipose Tissue (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Body Weight (日) (読) [継承]
5. (英) Diet, High-Fat (日) (読) [継承]
6. (英) Feeding Behavior (日) (読) [継承]
7. (英) Female (日) (読) [継承]
8. (英) Hypothalamus (日) (読) [継承]
9. (英) Interleukin-1 (日) (読) [継承]
10. (英) Leptin (日) (読) [継承]
11. (英) Ovariectomy (日) (読) [継承]
12. (英) RNA, Messenger (日) (読) [継承]
13. (英) Random Allocation (日) (読) [継承]
14. (英) Rats, Sprague-Dawley (日) (読) [継承]
15. (英) Testosterone (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Behavioural Brain Research ([Elsevier])
(pISSN: 0166-4328, eISSN: 1872-7549)

ISSN (任意): 1872-7549
ISSN: 0166-4328 (pISSN: 0166-4328, eISSN: 1872-7549)
Title: Behavioural brain research
Title(ISO): Behav Brain Res
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 349 [継承]
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(必須): 102 108 [継承]
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年月日 (必須): 西暦 2018年 3月 12日 (平成 30年 3月 12日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bbr.2018.02.021    (→Scopusで検索) [継承]
PMID (任意): 29544963    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.ELocationID: S0166-4328(18)30016-0  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/j.bbr.2018.02.021  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: Body weight  (日)    [継承]
5.(英) KeywordList.Keyword: High-fat diet preference  (日)    [継承]
6.(英) KeywordList.Keyword: Ovariectomy  (日)    [継承]
7.(英) KeywordList.Keyword: Testosterone  (日)    [継承]

標準的な表示

和文冊子 ● (種別) : Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Mayila Yiliyasi, Akira Kuwahara, Sumika Matsui and Minoru Irahara : Effects of chronic testosterone administration on the degree of preference for a high-fat diet and body weight in gonadal-intact and ovariectomized female rats., Behavioural Brain Research, Vol.349, (号), 102-108, (発行所), (都市), March 2018.
欧文冊子 ● (種別) : Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Mayila Yiliyasi, Akira Kuwahara, Sumika Matsui and Minoru Irahara : Effects of chronic testosterone administration on the degree of preference for a high-fat diet and body weight in gonadal-intact and ovariectomized female rats., Behavioural Brain Research, Vol.349, (号), 102-108, (発行所), (都市), March 2018.

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