| ○種別 (必須): |
| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 松崎 利也
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| 2. | 岩佐 武 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
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| 3. | (英) Yanagihara Rie (日) (読)
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| 4. | (英) Komasaka Mizuki (日) (読)
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| 5. | 矢野 清人
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 6. | (英) Mayila Yiliyasi (日) Mayila Yiliyasi (読) まいら いりやす
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| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 7. | (英) Tachibana Ayaka (日) (読)
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| 8. | 山本 由理 ([徳島大学.病院.中央診療施設等.地域産婦人科診療部]/[徳島大学.病院.診療科.小児·周産·女性科.産科婦人科])
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| 9. | 加藤 剛志
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| 10. | 桑原 章
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| 11. | 苛原 稔
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| ○題名 (必須): | □ | (英) Pilot study of the optimal protocol of low dose step-up follicle stimulating hormone therapy for infertile women. (日)
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| ○要約 (任意): | □ | (英) To evaluate the optimized protocol of low dose follicle-stimulating hormone (FSH) therapy that has a starting dose of 50 IU/62.5 IU with a small increment dose (12.5 IU) for women with World Health Organization (WHO) II ovulatory disorder and unexplained infertility. Anovulatory women with WHO group II ovulatory disorder (ovulation induction [OI] patients, n = 29), and with an unexplained infertility (ovarian stimulation [OS] patients, n = 21) were enrolled. The protocol of low dose step-up FSH therapy was optimized for the starting dose as 50 IU (body mass index [BMI] < 20 group) and 62.5 IU (BMI ≥ 20 group) with the increment dose of 12.5 IU. Study outcomes were ovulation, monofollicular development and other variables. In the OIpatients, the ovulation rate was 100% (BMI < 20 group) and 90.9% (BMI ≥ 20 group). Monofollicular development was 80.0% (BMI < 20) and 77.3% (BMI ≥ 20). The pregnancy rate was 60% (3/5 BMI < 20) and 18.2% (4/22 BMI ≥ 20). There was no multiple pregnancy. In the OSpatients, the ovulation rate was 100%. Monofollicular development was 85.7% (BMI < 20) and 76.6% (BMI ≥ 20). No pregnancy was achieved in the OSpatients. Optimized protocol of low dose FSH therapy setting a starting dose 50 IU/62.5 IU by BMI with an increment dose of 12.5 IU was safe and highly effective in WHO group II anovulatory patients. However, this protocol seemed uneffective for patients with unexplained infertility. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Reproductive Medicine and Biology (日本生殖医学会/日本アンドロロジー学会/日本受精着床学会)
(pISSN: 1445-5781, eISSN: 1447-0578)
| ○ISSN (任意): | □ | 1445-5781
ISSN: 1445-5781
(pISSN: 1445-5781, eISSN: 1447-0578) Title: Reproductive medicine and biologyTitle(ISO): Reprod Med BiolPublisher: Springer (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 17
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 315 324
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 6月 12日 (平成 30年 6月 12日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/rmb2.12208 (→Scopusで検索)
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| ○PMID (任意): | □ | 30013434 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1002/rmb2.12208 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: WHO group II (日)
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| 4. | (英) KeywordList.Keyword: low dose FSH (日)
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| 5. | (英) KeywordList.Keyword: ovarian stimulation (日)
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| 6. | (英) KeywordList.Keyword: ovulation induction (日)
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| 7. | (英) KeywordList.Keyword: polycystic ovary syndrome (日)
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