| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Fukuda-Tatano Shiori (日) 福田 詩織 (読) ふくだ しおり
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 山本 浩範
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| 3. | (英) Nakahashi Otoki (日) (読)
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| 4. | (英) Yoshikawa Ryouhei (日) (読)
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| 5. | (英) Hayashi Mayu (日) 林 眞由 (読) はやし まゆ
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| ○学籍番号 (推奨): | □ | ****
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| 6. | (英) Kishimoto Maki (日) 岸本 麻希 (読) きしもと まき
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| ○学籍番号 (推奨): | □ | ****
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| 7. | 伊美 友紀子
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| 8. | 奥村 仙示
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| 9. | 大西 康太
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| 10. | 増田 真志 ([徳島大学.大学院医歯薬学研究部.医学域.先端栄養学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.臨床食管理学])
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| 11. | 竹谷 豊 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.臨床食管理学])
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| ○題名 (必須): | □ | (英) Regulation of α-Klotho Expression by Dietary Phosphate During Growth Periods. (日)
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| ○要約 (任意): | □ | (英) (日) Inorganic phosphate (Pi) is an essential nutrient for maintaining various biological functions, particularly during growth periods. Excess intake of dietary Pi increases the secretion of fibroblast growth factor 23 (FGF23) and parathyroid hormone to maintain plasma Pi levels. FGF23 is a potent phosphaturic factor that binds to the α-klotho/FGFR complex in the kidney to promote excretion of Pi into the urine. In addition, excess intake of dietary Pi decreases renal α-klotho expression. Down-regulation or lack of α-klotho induces a premature aging-like phenotype, resulting from hyperphosphatemia, and leading to conditions such as ectopic calcification and osteoporosis. However, it remains unclear what effects dietary Pi has on α-klotho expression at different life stages, especially during growth periods. To investigate this, we used C57BL/6J mice in two life stages during growing period. Weaned (3 weeks old) and periadolescent (7 weeks old) were randomly divided into seven experimental groups and fed with 0.02, 0.3, 0.6, 0.9, 1.2, 1.5, or 1.8% Pi diets for 7 days. As a result, elevated plasma Pi and FGF23 levels and decreased renal α-klotho expression were observed in weaned mice fed with a high Pi diet. In addition, a high Pi diet clearly induced renal calcification in the weaned mice. However, in the periadolescent group, renal calcification was not observed, even in the 1.8% Pi diet group. The present study indicates that a high Pi diet in weaned mice has much greater adverse effects on renal α-klotho expression and pathogenesis of renal calcification compared with periadolescent mice.
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Calcified Tissue International (International Osteoporosis Foundation)
(pISSN: 0171-967X, eISSN: 1432-0827)
| ○ISSN (任意): | □ | 1432-0827
ISSN: 0171-967X
(pISSN: 0171-967X, eISSN: 1432-0827) Title: Calcified tissue internationalTitle(ISO): Calcif Tissue IntSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 104
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | 667 678
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2019年 1月 23日 (平成 31年 1月 23日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s00223-019-00525-0 (→Scopusで検索)
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| ○PMID (任意): | □ | 30671592 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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