『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Miki Akiko (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Sakurada Yoichi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Tanaka Koji (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Semba Kentaro (日) (読)
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学籍番号 (推奨):
[継承]
5.三田村 佳典 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.眼科学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Yuzawa Mitsuko (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Tajima Atsushi (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Nakatochi Masahiro (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Yamamoto Ken (日) (読)
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学籍番号 (推奨):
[継承]
10. (英) Matsuo Keitaro (日) (読)
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学籍番号 (推奨):
[継承]
11. (英) Imoto Issei (日) (読)
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学籍番号 (推奨):
[継承]
12. (英) Honda Shigeru (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Genome-wide association study to identify a new susceptibility locus for central serous chorioretinopathy in the Japanese population  (日)    [継承]
副題 (任意):
要約 (任意): (英) Central serous chorioretinopathy (CSC) is a retinal disorder that often affects the vision of middle-aged people yet the molecular mechanisms of CSC remain unknown. This study was conducted to identify genetic factors influencing individual differences in susceptibility to CSC. A two-stage genome-wide association study (GWAS) was conducted with a total of 320 unrelated Japanese idiopathic CSC cases and 3245 population-based controls. In a discovery stage, 137 unrelated Japanese idiopathic CSC cases and 1174 population-based controls were subjected to GWAS, followed by a replication study using an additional 183 individuals with idiopathic CSC and 2071 population-based volunteers. The results of the discovery and replication stages were combined to conduct a meta-analysis. In the two-stage GWAS, rs11865049 located at SLC7A5 in chromosome 16q24.2 was identified as a novel disease susceptibility locus for CSC, as evident from the discovery and replication results using meta-analysis (combined P = 9.71 × 10-9, odds ratio = 2.10). The results of the present study demonstrated that SLC7A5 might be the potential candidate gene associated with CSC, indicating a previously unidentified molecular mechanism of CSC.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Asian Continental Ancestry Group (日) (読) [継承]
4. (英) Central Serous Chorioretinopathy (日) (読) [継承]
5. (英) Chromosomes, Human, Pair 16 (日) (読) [継承]
6. (英) Disease Susceptibility (日) (読) [継承]
7.女性 (female) [継承]
8. (英) Genetic Predisposition to Disease (日) (読) [継承]
9. (英) Genome-Wide Association Study (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11.日本 (Japan) [継承]
12. (英) Large Neutral Amino Acid-Transporter 1 (日) (読) [継承]
13.男性 (male) [継承]
14. (英) Middle Aged (日) (読) [継承]
15. (英) Polymorphism, Single Nucleotide (日) (読) [継承]
16. (英) Tomography, Optical Coherence (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Investigative Ophthalmology & Visual Science (Association for Research in Vision and Ophthalmology)
(pISSN: 0146-0404, eISSN: 1552-5783)

ISSN (任意): 1552-5783
ISSN: 0146-0404 (pISSN: 0146-0404, eISSN: 1552-5783)
Title: Investigative ophthalmology & visual science
Title(ISO): Invest Ophthalmol Vis Sci
Publisher: Association for Research in Vision and Ophthalmology
 (NLM Catalog  (Scopus  (CrossRef  (CrossRef (Scopus information is found. [need login])
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(必須): 59 [継承]
(必須): 13 [継承]
(必須): 5542 5547 [継承]
都市 (任意):
年月日 (必須): 西暦 2018年 11月 1日 (平成 30年 11月 1日) [継承]
URL (任意):
DOI (任意): 10.1167/iovs.18-25497    (→Scopusで検索) [継承]
PMID (任意): 30480742    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85057233404 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1167/iovs.18-25497  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Akiko Miki, Yoichi Sakurada, Koji Tanaka, Kentaro Semba, Yoshinori Mitamura, Mitsuko Yuzawa, Atsushi Tajima, Masahiro Nakatochi, Ken Yamamoto, Keitaro Matsuo, Issei Imoto and Shigeru Honda : Genome-wide association study to identify a new susceptibility locus for central serous chorioretinopathy in the Japanese population, Investigative Ophthalmology & Visual Science, Vol.59, No.13, 5542-5547, 2018.
欧文冊子 ● Akiko Miki, Yoichi Sakurada, Koji Tanaka, Kentaro Semba, Yoshinori Mitamura, Mitsuko Yuzawa, Atsushi Tajima, Masahiro Nakatochi, Ken Yamamoto, Keitaro Matsuo, Issei Imoto and Shigeru Honda : Genome-wide association study to identify a new susceptibility locus for central serous chorioretinopathy in the Japanese population, Investigative Ophthalmology & Visual Science, Vol.59, No.13, 5542-5547, 2018.

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