『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=350688EID:350688, Map:0, LastModified:2019年8月21日(水) 17:22:59, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[沼田 周助], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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共著種別 (推奨): 学内共著 (徳島大学内研究者との共同研究 (学外研究者を含まない)) [継承]
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著者 (必須): 1.大田 将史
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学籍番号 (推奨): **** [ユーザ]
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2.中瀧 理仁 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])
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3.武田 知也 ([徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])
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学籍番号 (推奨): **** [ユーザ]
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4.沼田 周助 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.精神医学]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])
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5.富永 武男
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6.亀岡 尚美
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7.久保 弘子
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8.木下 誠 ([徳島大学.病院.先端医科医療開発研究プロジェクト]/[徳島大学.病院.診療科.脳·神経·精神科.精神科神経科])
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9. (英) Matsuura K (日) (読)
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10. (英) Otomo M (日) (読)
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11. (英) Takeichi N (日) (読)
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12.原田 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])
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13.大森 哲郎
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題名 (必須): (英) Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study.  (日)    [継承]
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要約 (任意): (英) Quality of life (QOL) is an important clinical outcome for patients with schizophrenia, and recent studies have focused on subjective QOL. We evaluated the causal relationship between psychosocial aspect of subjective QOL, symptoms, cognitive functions, and salience network (SN) dysfunction in schizophrenia using structural equation modeling (SEM). We performed a cross-sectional study of 21 patients with symptomatically stabilized schizophrenia and 21 age-, sex-, and education level-matched healthy controls who underwent resting-state functional magnetic resonance imaging. We evaluated SN dysfunction in schizophrenia using independent component analysis (ICA). We rated participant psychopathology using the Positive and Negative Syndrome Scale (PANSS), the Brief Assessment of Cognition in Schizophrenia (BACS), and the Calgary Depression Scale for Schizophrenia (CDSS). We rated psychosocial aspect of subjective QOL using the Schizophrenia Quality of Life Scale (SQLS) psychosocial subscale. We applied SEM to examine the relationships between SN dysfunction, PANSS positive and negative scores, CDSS total scores, BACS composite scores, and SQLS psychosocial subscale scores. In second-level analysis after group ICA, patient group had significant lower right pallidum functional connectivity (FC) within the SN than the controls did (Montreal Neurological Institute [MNI] [] = [22 -2 -6]) ( = 0.027, family-wise error [FWE] corrected). In SEM, we obtained a good fit for an SEM model in which SN dysfunction causes depressed mood, which in turn determines psychosocial aspect of subjective QOL (chi-squared = 0.9, root mean square error of approximation (RMSEA) < 0.001, comparative fit index [CFI] = 1.00, and standardized root mean square residual [SRMR]= 0.020). We found a continuous process by which SN dysfunction causes depressed moods that determine psychosocial aspect of subjective QOL in schizophrenia. This is the first report that offers a unified explanation of functional neuroimaging, symptoms, and outcomes. Future studies combining neuroimaging techniques and clinical assessments would elucidate schizophrenia's pathogenesis.  (日)    [継承]
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誌名 (必須): Neuropsychiatric Disease and Treatment ([International Neuropsychiatric Association])
(pISSN: 1176-6328, eISSN: 1178-2021)

ISSN (任意): 1176-6328
ISSN: 1176-6328 (pISSN: 1176-6328, eISSN: 1178-2021)
Title: Neuropsychiatric disease and treatment
Title(ISO): Neuropsychiatr Dis Treat
Publisher: Dove Medical Press Ltd
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 14 [継承]
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(必須): 1585 1597 [継承]
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年月日 (必須): 西暦 2018年 6月 15日 (平成 30年 6月 15日) [継承]
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DOI (任意): 10.2147/NDT.S163132    (→Scopusで検索) [継承]
PMID (任意): 29942132    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85048683537 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.2147/NDT.S163132  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: depressed mood  (日)    [継承]
4.(英) KeywordList.Keyword: resting-state fMRI  (日)    [継承]
5.(英) KeywordList.Keyword: salience network  (日)    [継承]
6.(英) KeywordList.Keyword: schizophrenia  (日)    [継承]
7.(英) KeywordList.Keyword: structural equation modeling  (日)    [継承]
8.(英) KeywordList.Keyword: subjective quality of life  (日)    [継承]
9.(英) CoiStatement: Disclosure The authors report no conflicts of interest in this work.  (日)    [継承]

標準的な表示

和文冊子 ● Masashi Ohta, Masahito Nakataki, Tomoya Takeda, Shusuke Numata, Takeo Tominaga, Naomi Kameoka, Hiroko Kubo, Makoto Kinoshita, K Matsuura, M Otomo, N Takeichi, Masafumi Harada and Tetsuro Ohmori : Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study., Neuropsychiatric Disease and Treatment, Vol.14, 1585-1597, 2018.
欧文冊子 ● Masashi Ohta, Masahito Nakataki, Tomoya Takeda, Shusuke Numata, Takeo Tominaga, Naomi Kameoka, Hiroko Kubo, Makoto Kinoshita, K Matsuura, M Otomo, N Takeichi, Masafumi Harada and Tetsuro Ohmori : Structural equation modeling approach between salience network dysfunction, depressed mood, and subjective quality of life in schizophrenia: an ICA resting-state fMRI study., Neuropsychiatric Disease and Treatment, Vol.14, 1585-1597, 2018.

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