| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | 小野 広幸
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| 2. | 村上 太一
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| 3. | 美馬 晶
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| 4. | 柴田 恵理子 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.腎臓内科学]/[徳島大学.病院.診療科.内科.腎臓内科])
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| 5. | 田蒔 昌憲 ([徳島大学.病院.中央診療施設等.検査部]/[徳島大学.病院.診療科.内科.腎臓内科])
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| 6. | 吉本 咲耶
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| 7. | (英) Ueda Sayo (日) (読)
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| 8. | (英) Kishi Fumi (日) (読)
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| 9. | 岸 誠司
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| 10. | 川中 崇 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学]/[徳島大学.病院.診療科.放射線科.放射線治療科])
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| 11. | 松浦 元一
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| 12. | 長井 幸二郎
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| 13. | 安部 秀斉
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| 14. | (英) Harada Masashi (日) (読)
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| 15. | 土井 俊夫
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| ○題名 (必須): | □ | (英) Successful treatment of highly advanced immunoglobulin G4-related kidney disease presenting renal mass-like regions with end-stage kidney failure: a case study. (日)
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| ○要約 (任意): | □ | (英) In immunoglobulin G4-related kidney disease with severe kidney failure, radiological findings should be carefully examined. In addition, renal prognosis may be good despite highly advanced tubulointerstitial nephritis and fibrosis. (日) A 59-year-old Japanese man was referred to our hospital because of uremia with a creatinine level of 12.36 mg/dL. Urinalysis revealed mild proteinuria and hyperβ2microglobulinuria, and blood tests showed hyperglobulinemia with an IgG level of 3243 mg/dL and an IgG4 level of 621 mg/dL. Non-contrast computed tomography revealed renal mass-like regions. Based on the findings, immunoglobulin G4-related kidney disease was suspected, however, further radiological examination showed unexpected results. Ga-67 scintigraphy showed no kidney uptake. T2-weighted magnetic resonance imaging revealed high-intensity signals which corresponded to mass-like regions and multiple patchy low-intensity signals in kidney cortex. Finally, the patient was diagnosed with immunoglobulin G4-related kidney disease by renal pathology of severe immunoglobulin G4-positive plasma cell-rich tubulointerstitial nephritis and characteristic fibrosis. He received 50 mg oral prednisolone, which was tapered with a subsequent decrease of serum creatinine and IgG4 levels. One year after initiation of treatment, he achieved normalization of serum IgG4 level and proteinuria, and remained off dialysis with a creatinine level of 3.50 mg/dL. After treatment with steroids, repeat imaging suggested bilateral severe focal atrophy. However, mass-like regions did not show atrophic change although renal atrophy was evident in patchy low-intensity lesions on T2-weighted magnetic resonance imaging. These findings suggest that multiple patchy low-intensity signals and high-intensity mass-like regions were mildly atrophic lesions of immunoglobulin G4-related kidney disease due to severe fibrosis and normal parts of kidney, respectively.
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| ○誌名 (必須): | □ | BMC Nephrology ([BioMed Central Ltd.])
(eISSN: 1471-2369)
| ○ISSN (任意): | □ | 1471-2369
ISSN: 1471-2369
(eISSN: 1471-2369) Title: BMC nephrologyTitle(ISO): BMC NephrolPublisher: BioMed Central (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 18
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 261 261
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| ○年月日 (必須): | □ | 西暦 2017年 8月 3日 (平成 29年 8月 3日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s12882-017-0676-5 (→Scopusで検索)
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| ○PMID (任意): | □ | 28774276 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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