| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sornborger Andrew (日) (読)
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| 2. | (英) Li Jie (日) (読)
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| 3. | (英) Timmons Cullen (日) (読)
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| 4. | (英) Lupu Floria (日) (読)
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| 5. | (英) Eggenschwiler Jonathan (日) (読)
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| 6. | 高浜 洋介
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| 7. | (英) Manley R. Nancy (日) (読)
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| ○貢献度 (任意): |
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| ○題名 (必須): | □ | (英) MiCASA is a new method for quantifying cellular organization. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) While many tools exist for identifying and quantifying individual cell types, few methods are available to assess the relationships between cell types in organs and tissues and how these relationships change during aging or disease states. We present a quantitative method for evaluating cellular organization, using the mouse thymus as a test organ. The thymus is the primary lymphoid organ responsible for generating T cells in vertebrates, and its proper structure and organization is essential for optimal function. Our method, Multitaper Circularly Averaged Spectral Analysis (MiCASA), identifies differences in the tissue-level organization with high sensitivity, including defining a novel type of phenotype by measuring variability as a specific parameter. MiCASA provides a novel and easily implemented quantitative tool for assessing cellular organization. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) CD11c Antigen (日) (読)
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| 3. | (英) Diagnosis, Computer-Assisted (日) (読)
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| 4. | (英) Genotype (日) (読)
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| 5. | (英) Image Processing, Computer-Assisted (日) (読)
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| 6. | (英) Lymphoid Tissue (日) (読)
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| 7. | (英) Male (日) (読)
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| 8. | (英) Mice (日) (読)
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| 9. | (英) Mice, Inbred BALB C (日) (読)
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| 10. | (英) Mice, Inbred C57BL (日) (読)
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| 11. | (英) Phenotype (日) (読)
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| 12. | (英) Spectrophotometry (日) (読)
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| 13. | (英) Spinal Cord (日) (読)
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| 14. | (英) T-Lymphocytes (日) (読)
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| 15. | (英) Thymus Gland (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Nature Communications ([Nature Publishing Group])
(eISSN: 2041-1723)
| ○ISSN (任意): | □ | 2041-1723
ISSN: 2041-1723
(eISSN: 2041-1723) Title: Nature communicationsTitle(ISO): Nat CommunPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 8
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| ○号 (必須): |
| ○頁 (必須): | □ | 15619 15619
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| ○年月日 (必須): | □ | 西暦 2017年 5月 30日 (平成 29年 5月 30日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/ncomms15619 (→Scopusで検索)
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| ○PMID (任意): | □ | 28555660 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1038/ncomms15619 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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