| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士前期課程学生による研究報告
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| ○組織 (推奨): | 1. | 徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野 (2017年4月1日〜)
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| ○著者 (必須): | 1. | (英) Noma Kazuki (日) (読)
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| 2. | (英) Kurauchi Yuki (日) (読)
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| 3. | (英) Katsuki Hiroshi (日) (読)
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| 4. | 小山 保夫
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| 5. | (英) Akaike Noriko (日) (読)
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| ○題名 (必須): | □ | (英) Intra-axonal Ca2+ mobilization contributes to triphenyltin-induced facilitation in glycinergic transmission of rat spinal neurons (日)
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| ○要約 (任意): | □ | (英) Triphenyltin (TPT) is an organotin compound causing environmental hazard to many wild creatures. Our previous findings show that TPT increases of the frequency of spontaneous glycinergic inhibitory postsynaptic currents (sIPSCs) in rat spinal neurons without changing the amplitude and 1/e decay time. In our study, the effects of 2-aminoethoxydiphenyl borate (2-APB), dantrolene sodium, and thapsigargin on sIPSC frequency were examined to reveal the contribution of intra-axonal Ca2+ mobilization by adding TPT. 2-APB considerably attenuated the TPT-induced facilitation of sIPSC frequency while dantrolene almost completely masked the TPT effects, suggesting that the TPT-induced synaptic facilitation results from the activation of both IP3 and ryanodine receptors on endoplasmic reticulum (ER) membrane, though inositol triphosphate (IP3) receptor is less sensitive to TPT. Thapsigargin itself significantly increased the sIPSC frequency without affecting the current amplitude and decay time. Successive addition of TPT could not further increase the sIPSC frequency in the presence of thapsigargin, indicating that thapsigargin completely masked the facilitatory action of TPT. Results suggest that TPT activates the IP3 and ryanodine receptors while TPT inhibits the Ca2+-pump of ER membranes, resulting in the elevation of intra-axonal Ca2+ levels, leading to the increase of spontaneous glycine release from synaptic vesicles. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): | □ | Elsevier (->組織[Elsevier Science])
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| ○誌名 (必須): | □ | Toxicology In Vitro (British Industrial Biological Research Association)
(pISSN: 0887-2333, eISSN: 1879-3177)
| ○ISSN (任意): | □ | 0887-2333
ISSN: 0887-2333
(pISSN: 0887-2333, eISSN: 1879-3177) Title: Toxicology in vitro : an international journal published in association with BIBRATitle(ISO): Toxicol In VitroPublisher: Elsevier Ltd (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 55
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 11 14
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2019年 3月 1日 (平成 31年 3月 1日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.tiv.2018.11.003 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-85056660675
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| ○評価値 (任意): | □ | ****
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