『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=345432EID:345432, Map:0, LastModified:2018年9月5日(水) 16:50:57, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[廣島 佑香], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨): 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない)) [継承]
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著者 (必須): 1.廣島 佑香 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔微生物学])
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2.山本 武範
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3. (英) Watanabe Masahiro (日) (読)
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4.馬場 嘉信
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5.篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
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題名 (必須): (英) Effects of cold exposure on metabolites in brown adipose tissue of rats.  (日)    [継承]
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要約 (任意): (英)   (日) Brown adipose tissue (BAT) plays an important role in regulation of energy expenditure while adapting to a cold environment. BAT thermogenesis depends on uncoupling protein 1 (UCP1), which is expressed in the inner mitochondrial membranes of BAT. Gene expression profiles induced by cold exposure in BAT have been studied, but the metabolomic biological pathway that contributes to the activation of thermogenesis in BAT remains unclear. In this study, we comprehensively compared the relative levels of metabolites between the BAT of rats kept at room temperature (22 °C) and of those exposed to a cold temperature (4 °C) for 48 h using capillary electrophoresis (CE) time-of-flight mass spectrometry (TOFMS) and liquid chromatography (LC)-TOFMS. We identified 218 metabolites (137 cations and 81 anions) by CE-TOFMS and detected 81 metabolites (47 positive and 34 negative) by LC-TOFMS in BAT. We found that cold exposure highly influenced the BAT metabolome. We showed that the cold environment lead to lower levels of glycolysis and gluconeogenesis intermediates and higher levels of the tricarboxylic acid (TCA) cycle metabolites, fatty acids, and acyl-carnitine metabolites than control conditions in the BAT of rats. These results indicate that glycolysis and β-oxidation of fatty acids in BAT are positive biological pathways that contribute to the activation of thermogenesis by cold exposure, thereby facilitating the generation of heat by UCP1. These data provide useful information for understanding the basal metabolic functions of BAT thermogenesis in rats in response to cold exposure.   [継承]
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誌名 (必須): Molecular Genetics and Metabolism Reports ([Elsevier])
(eISSN: 2214-4269)

ISSN (任意): 2214-4269
ISSN: 2214-4269 (eISSN: 2214-4269)
Title: Molecular genetics and metabolism reports
Title(ISO): Mol Genet Metab Rep
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 15 [継承]
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(必須): 36 42 [継承]
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年月日 (必須): 西暦 2018年 2月 3日 (平成 30年 2月 3日) [継承]
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DOI (任意): 10.1016/j.ymgmr.2018.01.005    (→Scopusで検索) [継承]
PMID (任意): 30023288    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yuka Hiroshima, Takenori Yamamoto, Masahiro Watanabe, Yoshinobu Baba and Yasuo Shinohara : Effects of cold exposure on metabolites in brown adipose tissue of rats., Molecular Genetics and Metabolism Reports, Vol.15, (号), 36-42, 2018.
欧文冊子 ● Yuka Hiroshima, Takenori Yamamoto, Masahiro Watanabe, Yoshinobu Baba and Yasuo Shinohara : Effects of cold exposure on metabolites in brown adipose tissue of rats., Molecular Genetics and Metabolism Reports, Vol.15, (号), 36-42, 2018.

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