| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
| [継承] |
| ○カテゴリ (推奨): | □ | 研究
| [継承] |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
| [継承] |
| ○学究種別 (推奨): | □ | 学士課程学生による研究報告
| [継承] |
| ○組織 (推奨): | 1. | 徳島大学.大学院生物資源産業学研究部.生物資源産業学部門.生物資源産業学系 (2016年4月1日〜)
| [継承] |
| 2. | 徳島大学.生物資源産業学部.生物資源産業学科.食料科学コース (2016年4月1日〜)
| [継承] |
| ○著者 (必須): | 1. | (英) Inoue Tomomi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 2. | (英) Kinoshita Maika (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 3. | (英) Oyama Keisuke (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Norio Kamemura (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 小山 保夫
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Captan-induced increase in the concentrations of intracellular Ca2+ and Zn2+ and its correlation with oxidative stress in rat thymic lymphocytes (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Captan, a phthalimide fungicide, is considered to be relatively nontoxic to mammals. There is a possibility that captan affects membrane and cellular parameters of mammalian cells, resulting in adverse effects, because of high residue levels. To test the possibility, we examined the effects of captan on rat thymic lymphocytes using flow-cytometry with appropriate fluorescent probes. Treatment with 10 and 30 µM captan induced apoptotic and necrotic cell death. Before cell death occurred, captan elevated the intracellular concentrations of Ca2+ and Zn2+ and decreased the concentration of cellular thiol compounds. These captan-induced phenomena are shown to cause cell death and are similar to those caused by oxidative stress. Captan also elevated the cytotoxicity of hydrogen peroxide. Results indicate that 10 and 30 µM captan cause cytotoxic effects on mammalian cells. Despite no report on the significant environmental toxicity hazard of captan in humans, it may exhibit adverse effects, described above, on wild organisms. (日)
| [継承] |
| ○キーワード (推奨): | 1. | 細胞毒性 (cytotoxicity)
| [継承] |
| 2. | カルシウム (calcium)
| [継承] |
| 3. | 環境汚染物質 (Environmental pollutants)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Environmental Toxicology and Pharmacology (European Journal of Pharmacology: Environmental Toxicology and Pharmacology)
(pISSN: 1382-6689, eISSN: 1872-7077)
| ○ISSN (任意): | □ | 1872-7077
ISSN: 1382-6689
(pISSN: 1382-6689, eISSN: 1872-7077) Title: Environmental toxicology and pharmacologyTitle(ISO): Environ Toxicol PharmacolPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 63
| [継承] |
| ○号 (必須): | □ |
| [継承] |
| ○頁 (必須): | □ | 78 83
| [継承] |
| ○都市 (任意): | □ | アムステルダム (Amsterdam/[オランダ王国])
| [継承] |
| ○年月日 (必須): | □ | 西暦 2018年 8月 27日 (平成 30年 8月 27日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.etap.2018.08.017 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 30172959 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○機関リポジトリ : | □ | 112166
| [継承] |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: S1382-6689(18)30301-6 (日)
| [継承] |
| 2. | (英) Article.ELocationID: 10.1016/j.etap.2018.08.017 (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 4. | (英) KeywordList.Keyword: Captan (日)
| [継承] |
| 5. | (英) KeywordList.Keyword: Intracellular Ca(2+) (日)
| [継承] |
| 6. | (英) KeywordList.Keyword: Intracellular Zn(2+) (日)
| [継承] |
| 7. | (英) KeywordList.Keyword: Lymphocytes (日)
| [継承] |
| 8. | (英) KeywordList.Keyword: Nonprotein thiols (日)
| [継承] |
| 9. | (英) KeywordList.Keyword: Superoxide anions (日)
| [継承] |