| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Maruhashi Tatsuya (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | (英) Higashi Yukihito (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Kihara Yasuki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Ueda Shinichiro (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Odawara Masato (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Terauchi Yasuo (日) (読)
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| [継承] |
| 9. | (英) Dai Kazuoki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 10. | (英) Ohno Jun (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 11. | (英) Iida Masato (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 12. | (英) Sano Hiroaki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 13. | (英) Tomiyama Hirofumi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 14. | (英) Inoue Teruo (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 15. | (英) Tanaka Atsushi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 16. | (英) Murohara Toyoaki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 17. | (英) Node Koichi (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Long-term effect of sitagliptin on endothelial function in type 2 diabetes: a sub-analysis of the PROLOGUE study. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) As a sub-analysis of the PROLOGUE study, we evaluated the long-term effect of sitagliptin, a dipeptidyl peptidase 4 inhibitor, on endothelial function in the conduit brachial artery in patients with type 2 diabetes. In the PROLOGUE study, patients were randomly assigned to either add-on sitagliptin treatment (sitagliptin group) or continued conventional antihyperglycemic treatment (conventional group). Among the 463 participants in the PROLOGUE study, FMD was measured in 17 patients in the sitagliptin group and 18 patients in the conventional group at the beginning and after 12 and 24 months of treatment. HbA1c levels were significantly decreased after 12 and 24 months of treatment compared to baseline values in both groups (7.0 0.4 vs. 6.6 0.3 and 6.6 0.4 % in the sitagliptin group; 7.0 0.6 vs. 6.6 0.7 and 6.6 0.7 % in the conventional group; P < 0.05, respectively). There was no significant difference between FMD values at baseline and after 12 and 24 months in the sitagliptin group (4.3 2.6 vs. 4.4 2.1 and 4.4 2.3 %, P = 1.0, respectively). Although FMD had a tendency to increase from 4.3 2.4 % at baseline to 5.2 1.9 % after 12 months and 5.1 2.2 % after 24 months in the conventional group, there was no significant difference between FMD values at baseline and after 12 and 24 months (P = 0.36 and 0.33, respectively). Add-on sitagliptin to conventional antihyperglycemic drugs in patients with type 2 diabetes did not alter endothelial function in the conduit brachial artery measured by FMD during a 2-year study period. Sitagliptin may be used without concern for an adverse effect on endothelial function in patients with type 2 diabetes. University hospital Medical Information Network (UMIN) Center: ID UMIN000004490. (日)
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| ○キーワード (推奨): | 1. | (英) Aged (日) (読)
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| 2. | (英) Biomarkers (日) (読)
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| 3. | (英) Blood Glucose (日) (読)
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| 4. | (英) Brachial Artery (日) (読)
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| 5. | (英) Diabetes Mellitus, Type 2 (日) (読)
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| 6. | (英) Dipeptidyl-Peptidase IV Inhibitors (日) (読)
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| 7. | (英) Drug Therapy, Combination (日) (読)
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| 8. | (英) Endothelium, Vascular (日) (読)
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| 9. | (英) Female (日) (読)
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| 10. | (英) Glycated Hemoglobin A (日) (読)
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| 11. | (英) Humans (日) (読)
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| 12. | 日本 (Japan)
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| 13. | (英) Male (日) (読)
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| 14. | (英) Middle Aged (日) (読)
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| 15. | (英) Prospective Studies (日) (読)
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| 16. | (英) Sitagliptin Phosphate (日) (読)
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| 17. | (英) Time Factors (日) (読)
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| 18. | (英) Treatment Outcome (日) (読)
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| 19. | (英) Vasodilation (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cardiovascular Diabetology ([BioMed Central Ltd.])
(eISSN: 1475-2840)
| ○ISSN (任意): | □ | 1475-2840
ISSN: 1475-2840
(eISSN: 1475-2840) Title: Cardiovascular diabetologyTitle(ISO): Cardiovasc DiabetolPublisher: BioMed Central (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 15
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 134 134
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 9月 13日 (平成 28年 9月 13日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1186/s12933-016-0438-x (→Scopusで検索)
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| ○PMID (任意): | □ | 27624168 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS : | □ | 000383842100004
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| ○Scopus (任意): | 1. | 2-s2.0-84992361845
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| ○researchmap (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1186/s12933-016-0438-x (日)
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| 2. | (英) Article.DataBankList.DataBank.DataBankName: UMIN CTR (日)
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| 3. | (英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: JPRN/UMIN000004490 (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 5. | (英) Article.PublicationTypeList.PublicationType: Multicenter Study (日)
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| 6. | (英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial (日)
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| 7. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 8. | (英) KeywordList.Keyword: Dipeptidyl peptidase 4 inhibitor (日)
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| 9. | (英) KeywordList.Keyword: Flow-mediated vasodilation (日)
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| 10. | (英) KeywordList.Keyword: Type 2 diabetes (日)
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