『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=343834)

EID=343834EID:343834, Map:0, LastModified:2018年10月15日(月) 13:36:18, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[福森 知治], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Shintani Terumichi (日) (読)
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[継承]
2.楠原 義人 ([徳島大学.病院.診療科.外科.泌尿器科])
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[継承]
3. (英) Daizumoto Kei (日) (読)
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[継承]
4. (英) Dondoo Tsogt-Ochir (日) (読)
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[継承]
5.山本 恭代 ([徳島大学.病院.診療科.外科.泌尿器科])
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[継承]
6.森 英恭
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学籍番号 (推奨):
[継承]
7.布川 朋也 ([徳島大学.病院.診療科.外科.泌尿器科])
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学籍番号 (推奨):
[継承]
8.中逵 弘能
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学籍番号 (推奨):
[継承]
9.福森 知治
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学籍番号 (推奨):
[継承]
10.高橋 正幸 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.泌尿器科学]/[徳島大学.病院.診療科.外科.泌尿器科])
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学籍番号 (推奨):
[継承]
11.金山 博臣 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.泌尿器科学])
役割 (任意):
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学籍番号 (推奨):
[継承]
題名 (必須): (英) The Involvement of Hepatocyte Growth Factor-MET-Matrix Metalloproteinase 1 Signaling in Bladder Cancer Invasiveness and Proliferation. Effect of the MET Inhibitor, Cabozantinib (XL184), on Bladder Cancer Cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) To clarify the invasive mechanisms of muscle-invasive bladder cancer (BCa) would be useful for the determination of appropriate treatment strategies. We previously showed that hepatocyte growth factor (HGF)-MET signaling is correlated with invasiveness of BCa cells. Here, we investigated the effects of the MET inhibitor, cabozantinib (XL184), on BCa cells. We first conducted Western blot analysis to investigate MET expression in BCa cell lines. Next, we examined the effect of cabozantinib on their proliferation and invasive abilities using MTT and Matrigel invasion assays, respectively. Invasion assays were performed using the xCELLigence system. Additionally, to investigate the biological function of HGF-MET signaling, we analyzed gene expression profiles and performed real-time polymerase chain reaction analyses of 5637 cells that were cultivated with or without HGF stimulation, with or without cabozantinib. MET was highly expressed in 4 of 5 BCa cell lines, and 5637 and T24 cells showed especially high protein expression of MET. Cabozantinib suppressed cell proliferation and invasion (cell index; mock, 1.49 vs HGF, 2.26 vs HGF + XL184, 1.47, P < .05). Gene expression profile analysis indicated that matrix metalloproteinase 1 (MMP1) was significantly elevated at the mRNA level with addition of HGF. Moreover, cabozantinib suppressed HGF-induced MMP1 expression in 5637 T24 cells. These data indicate that cabozantinib suppressed MMP1 expression by blocking HGF-MET signaling and that HGF-MET-MMP1 signaling is involved in the invasiveness and proliferation of BCa cells. These results suggest that cabozantinib might prove useful for future treatment of muscle-invasive BCa.  (日)    [継承]
キーワード (推奨): 1. (英) Anilides (日) (読) [継承]
2. (英) Blotting, Western (日) (読) [継承]
3. (英) Cell Count (日) (読) [継承]
4. (英) Cell Line, Tumor (日) (読) [継承]
5. (英) Cell Proliferation (日) (読) [継承]
6. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
7. (英) Hepatocyte Growth Factor (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Matrix Metalloproteinase 1 (日) (読) [継承]
10. (英) Neoplasm Invasiveness (日) (読) [継承]
11. (英) Protein Array Analysis (日) (読) [継承]
12. (英) Proto-Oncogene Proteins c-met (日) (読) [継承]
13. (英) Pyridines (日) (読) [継承]
14. (英) RNA, Neoplasm (日) (読) [継承]
15. (英) Receptor Protein-Tyrosine Kinases (日) (読) [継承]
16. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
17.シグナル伝達 (signal transduction) [継承]
18. (英) Urinary Bladder (日) (読) [継承]
19. (英) Urinary Bladder Neoplasms (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Urology (Société Internationale d' Urologie)
(pISSN: 0090-4295, eISSN: 1527-9995)

ISSN (任意): 1527-9995
ISSN: 0090-4295 (pISSN: 0090-4295, eISSN: 1527-9995)
Title: Urology
Title(ISO): Urology
Publisher: Elsevier Inc.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 101 [継承]
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(必須): 169.e7 169.e13 [継承]
都市 (任意):
年月日 (必須): 西暦 2017年 3月 初日 (平成 29年 3月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.urology.2016.12.006    (→Scopusで検索) [継承]
PMID (任意): 28013036    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85009932260 [継承]
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備考 (任意): 1.(英) Article.ELocationID: S0090-4295(16)30945-1  (日)    [継承]
2.(英) Article.ELocationID: 10.1016/j.urology.2016.12.006  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Terumichi Shintani, Yoshito Kusuhara, Kei Daizumoto, Tsogt-Ochir Dondoo, Yasuyo Yamamoto, Hidehisa Mori, Tomoya Fukawa, Hiroyoshi Nakatsuji, Tomoharu Fukumori, Masayuki Takahashi and Hiro-omi Kanayama : The Involvement of Hepatocyte Growth Factor-MET-Matrix Metalloproteinase 1 Signaling in Bladder Cancer Invasiveness and Proliferation. Effect of the MET Inhibitor, Cabozantinib (XL184), on Bladder Cancer Cells., Urology, Vol.101, 169.e7-169.e13, 2017.
欧文冊子 ● Terumichi Shintani, Yoshito Kusuhara, Kei Daizumoto, Tsogt-Ochir Dondoo, Yasuyo Yamamoto, Hidehisa Mori, Tomoya Fukawa, Hiroyoshi Nakatsuji, Tomoharu Fukumori, Masayuki Takahashi and Hiro-omi Kanayama : The Involvement of Hepatocyte Growth Factor-MET-Matrix Metalloproteinase 1 Signaling in Bladder Cancer Invasiveness and Proliferation. Effect of the MET Inhibitor, Cabozantinib (XL184), on Bladder Cancer Cells., Urology, Vol.101, 169.e7-169.e13, 2017.

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