| ○種別 (必須): | □ | 総説·解説
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| ○言語 (必須): | □ | 英語
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kawashita Yoichiro (日) (読)
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| 2. | 森根 裕二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 3. | 池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 4. | 齋藤 裕 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 5. | 岩橋 衆一
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| 6. | 山田 眞一郎 ([徳島大学.病院.診療科.外科.消化器・移植外科])
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| 7. | 東島 潤
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| 8. | 居村 暁
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| 9. | 小川 博久 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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| 10. | (英) Yagi Toshiyuki (日) (読)
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| 11. | 島田 光生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.消化器・移植外科学])
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| ○題名 (必須): | □ | (英) Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis. (日)
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| ○要約 (任意): | □ | (英) Fbxw7 is a tumor suppressor through ubiquitination and degradation of multiple oncoproteins. Loss of Fbxw7 is frequently observed in various human cancers. In this study, we examined the role of Fbxw7 expression in colorectal liver metastasis (CRLM) and its mechanism. Fifty-six patients with CRLM who undergo curative resection were enrolled. Fbxw7 in tumor tissue was determined by immunohistochemistry. Patients were divided into two groups, the Fbxw7 high and low groups. Clinicopathological factors including miR-223 expression were compared between the high (n = 32) and low Fbxw7 groups (n = 24). Fbxw7 expression in tumor tissues was significantly lower than that in normal tissues. The disease-free survival in the low Fbxw7 group was significantly worse than that in the high Fbxw7 group, and 3 years disease-free survival of the low and high Fbxw7 groups were 12.5% and 47.0%, respectively (P = 0.023). On multivariate analysis, loss of Fbxw7 was detected as one of the independent risk factors for recurrence of CRLM (hazard ratio: 2.390, P = 0.017). Likewise, Fbxw7 expression inversely correlated to miR-223 expression (P = 0.017). Loss of Fbxw7 in tumor tissues could be a reliable predictor of recurrence after hepatectomy in patients with CRLM, and miR-223 might be a possible regulator of Fbxw7. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Journal of Hepato-Biliary-Pancreatic Sciences (日本肝胆膵外科学会/Asian-Pacific Hepato-Pancreato-Biliary Association)
(pISSN: 1868-6974, eISSN: 1868-6982)
| ○ISSN (任意): | □ | 1868-6982
ISSN: 1868-6974
(pISSN: 1868-6974, eISSN: 1868-6982) Title: Journal of hepato-biliary-pancreatic sciencesTitle(ISO): J Hepatobiliary Pancreat SciSupplier: Japanese Society of Hepato-Biliary-Pancreatic SurgeryPublisher: Wiley Publishing (NLM Catalog)
(医中誌Web)
(Wiley)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 24
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| ○号 (必須): | □ | 10
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| ○頁 (必須): | □ | 576 583
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 10月 12日 (平成 29年 10月 12日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/jhbp.500 (→Scopusで検索)
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| ○PMID (任意): | □ | 28846828 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1002/jhbp.500 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Colorectal liver metastasis (日)
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| 4. | (英) KeywordList.Keyword: Fbxw7 (日)
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| 5. | (英) KeywordList.Keyword: Prognostic factor (日)
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| 6. | (英) KeywordList.Keyword: miR-223 (日)
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