| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | (英) Miyagawa Yoshimasa (日) 宮川 義仁 (読) みやがわ よしまさ
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| ○学籍番号 (推奨): | □ | ****
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| 2. | 松下 洋輔
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| 3. | (英) Suzuki Hiromu (日) (読)
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| 4. | 小松 正人
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| 5. | 吉丸 哲郎 ([徳島大学.先端酵素学研究所.重点研究部門])
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| 6. | 木村 竜一朗
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| 7. | (英) Yanai Ayako (日) (読)
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| 8. | (英) Honda Junko (日) (読)
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| 9. | 丹黒 章
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| 10. | (英) Sasa Mitsunori (日) (読)
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| 11. | (英) Miyoshi Yasuo (日) (読)
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| 12. | 片桐 豊雅
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| ○題名 (必須): | □ | (英) Frequent downregulation of LRRC26 by epigenetic alterations is involved in the malignant progression of triple-negative breast cancer. (日)
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| ○要約 (任意): | □ | (英) (日) Triple-negative breast cancer (TNBC), defined as breast cancer lacking estrogen- and progesterone‑receptor expression and human epidermal growth factor receptor 2 (HER2) amplification, is a heterogeneous disease. RNA-sequencing analysis of 15 TNBC specimens and The Cancer Genome Atlas-TNBC dataset analysis identified the frequent downregulation of leucine-rich repeat-containing 26 (LRRC26), which negatively regulates nuclear factor-κB (NF-κB) signaling, in TNBC tissues. Quantitative polymerase chain reaction and bisulfite pyrosequencing analyses revealed that LRRC26 was frequently silenced in TNBC tissues and cell lines as a result of promoter methylation. LRRC26 expression was restored by 5-aza-2'-deoxycytidine (5'-aza-dC) treatment in HCC1937 TNBC cells, which lack LRRC26 expression. Notably, small interfering RNA-mediated knockdown of LRRC26 expression significantly enhanced the anchorage-independent growth, invasion and migration of HCC70 cells, whereas ectopic overexpression of LRRC26 in BT20 cells suppressed their invasion and migration. Conversely, neither knockdown nor overexpression of LRRC26 had an effect on cell viability in the absence of tumor necrosis factor-α (TNF-α) stimulation. Meanwhile, overexpression of LRRC26 caused the reduction of TNF-α-mediated NF-κB luciferase reporter activity, whereas depleting LRRC26 expression resulted in the upregulation of TNF-α-mediated NF-κB downstream genes [interleukin-6 (IL-6), IL-8 and C-X-C motif chemokine ligand-1]. Taken together, these findings demonstrate that LRRC26 is frequently downregulated in TNBC due to DNA methylation and that it suppresses the TNF-α-independent anchorage-independent growth, invasion and migration of TNBC cells. Loss of LRRC26 function may be a critical event in the aggressiveness of TNBC cells through a TNF-α/NF-κB-independent mechanism.
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | International Journal of Oncology (International Center for Cancer Research)
(pISSN: 1019-6439, eISSN: 1791-2423)
| ○ISSN (任意): | □ | 1791-2423
ISSN: 1019-6439
(pISSN: 1019-6439, eISSN: 1791-2423) Title: International journal of oncologyTitle(ISO): Int J OncolPublisher: Spandidos Publications (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): |
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| ○年月日 (必須): | □ | 西暦 2018年 3月 5日 (平成 30年 3月 5日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3892/ijo.2018.4301 (→Scopusで検索)
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| ○PMID (任意): | □ | 29512727 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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