『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=339441EID:339441, Map:0, LastModified:2019年7月23日(火) 14:28:59, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[佐田 政隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hara Tomoya (日) (読)
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[継承]
2. (英) Phuong Tran Pham (日) (読)
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[継承]
3.福田 大受 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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[継承]
4.山口 浩司 ([徳島大学.病院.診療科.内科.循環器内科])
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[継承]
5. (英) Murata Chie (日) (読)
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[継承]
6. (英) Nishimoto Sachiko (日) (読)
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[継承]
7.八木 秀介 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域医療人材育成(医学域)])
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[継承]
8.楠瀬 賢也 ([徳島大学.病院.診療科.内科.循環器内科])
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[継承]
9.山田 博胤 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).地域循環器内科学])
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[継承]
10. (英) Takeshi Soeki (日) (読)
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[継承]
11.若槻 哲三 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学]/[徳島大学.病院.診療科.内科.循環器内科])
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[継承]
12. (英) Imoto Issei (日) (読)
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[継承]
13.島袋 充生
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14.佐田 政隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.循環器内科学])
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[継承]
題名 (必須): (英) Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice.  (日)    [継承]
副題 (任意):
要約 (任意): (英) -The coagulation system is closely linked with vascular inflammation, although the underlying mechanisms are still obscure. Recent studies show that protease-activated receptor (PAR)-2, a major receptor of activated factor X (FXa), are expressed in both vascular cells and leukocytes, suggesting that PAR-2 may contribute to the pathogenesis of inflammatory diseases. Here we investigated the role of PAR-2 in vascular inflammation and atherogenesis. -We generated apolipoprotein E-deficient ( ) mice lacking systemic PAR-2 expression ( ). mice which lack or express PAR-2 only in bone-marrow (BM) cells were also generated by BM transplantation. Atherosclerotic lesions were investigated after 20 weeks on a western-type diet (WTD) by histological analyses, quantitative RT-PCR, and western blotting. In vitro experiments using BM-derived macrophages were performed to confirm pro-inflammatory roles of PAR-2. The association between plasma FXa level and the severity of coronary atherosclerosis was also examined in humans who underwent coronary intervention. - mice showed reduced atherosclerotic lesions in the aortic arch (<0.05) along with features of stabilized atherosclerotic plaques such as less lipid deposition (<0.05), collagen loss (<0.01), macrophage accumulation (<0.05), and inflammatory molecule expression (<0.05) compared with mice. Systemic PAR2 deletion in mice significantly decreased the expression of inflammatory molecules in the aorta. The results of BM transplantation experiments demonstrated that PAR-2 in hematopoietic cells contributed to atherogenesis in mice. PAR-2 deletion did not alter metabolic parameters. In vitro experiments demonstrated that FXa or a specific peptide agonist of PAR-2 significantly increased expression of inflammatory molecules and lipid uptake in BM-derived macrophages from wild-type mice compared with those from PAR-2-deficient mice. Activation of NF- κB signaling was involved in PAR-2-associated vascular inflammation and macrophage activation. In humans who underwent coronary intervention, plasma FXa level independently correlated with the severity of coronary atherosclerosis as determined by Gensini score (<0.05) and plaque volume (<0.01). -PAR-2 signaling activates macrophages and promotes vascular inflammation, increasing atherosclerosis in mice. This signaling pathway may also participate in atherogenesis in humans.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): Circulation ([American Heart Association])
(pISSN: 0009-7322, eISSN: 1524-4539)

ISSN (任意): 1524-4539
ISSN: 0009-7322 (pISSN: 0009-7322, eISSN: 1524-4539)
Title: Circulation
Title(ISO): Circulation
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 138 [継承]
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(必須): 1706 1719 [継承]
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年月日 (必須): 西暦 2018年 4月 26日 (平成 30年 4月 26日) [継承]
URL (任意):
DOI (任意): 10.1161/CIRCULATIONAHA.118.033544    (→Scopusで検索) [継承]
PMID (任意): 29700120    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85055611443 [継承]
機関リポジトリ : 112891 [継承]
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備考 (任意): 1.(英) Article.ELocationID: CIRCULATIONAHA.118.033544  (日)    [継承]
2.(英) Article.ELocationID: 10.1161/CIRCULATIONAHA.118.033544  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) KeywordList.Keyword: atherosclerosis  (日)    [継承]
5.(英) KeywordList.Keyword: inflammation  (日)    [継承]
6.(英) KeywordList.Keyword: macrophage  (日)    [継承]
7.(英) KeywordList.Keyword: protease-activated receptor-2  (日)    [継承]

標準的な表示

和文冊子 ● Tomoya Hara, Pham Tran Phuong, Daiju Fukuda, Koji Yamaguchi, Chie Murata, Sachiko Nishimoto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Soeki Takeshi, Tetsuzo Wakatsuki, Issei Imoto, Michio Shimabukuro and Masataka Sata : Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice., Circulation, Vol.138, No.16, 1706-1719, 2018.
欧文冊子 ● Tomoya Hara, Pham Tran Phuong, Daiju Fukuda, Koji Yamaguchi, Chie Murata, Sachiko Nishimoto, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Soeki Takeshi, Tetsuzo Wakatsuki, Issei Imoto, Michio Shimabukuro and Masataka Sata : Protease-Activated Receptor-2 Plays a Critical Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-Deficient Mice., Circulation, Vol.138, No.16, 1706-1719, 2018.

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