『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.岩佐 武 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
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2.松崎 利也
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3.矢野 清人
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学籍番号 (推奨): **** [ユーザ]
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4. (英) Yanagihara Rie (日) (読)
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5. (英) Mayila Yiliyasi (日) 馬依拉 伊利亜斯 (読) まいら いりやす
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6.苛原 稔 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.産科婦人科学])
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題名 (必須): (英) The effects of chronic testosterone administration on hypothalamic gonadotropin-releasing hormone regulatory factors (Kiss1, NKB, pDyn and RFRP) and their receptors in female rats.  (日)    [継承]
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要約 (任意): (英) The effects of androgens on gonadotropin-releasing hormone (GnRH) secretion in females have not been fully established. To clarify the direct effects of androgens on hypothalamic reproductive factors, we evaluated the effects of chronic testosterone administration on hypothalamic GnRH regulatory factors in ovariectomized (OVX) female rats. Both testosterone and estradiol reduced the serum luteinizing hormone levels of OVX female rats, indicating that, as has been found for estrogen, testosterone suppresses GnRH secretion via negative feedback. Similarly, the administration of testosterone or estradiol suppressed the hypothalamic mRNA levels of kisspeptin and neurokinin B, both of which are positive regulators of GnRH, whereas it did not affect the hypothalamic mRNA levels of the kisspeptin receptor or neurokinin-3 receptor. On the contrary, the administration of testosterone, but not estradiol, suppressed the hypothalamic mRNA expression of prodynorphin, which is a negative regulator of GnRH. The administration of testosterone did not alter the rats' serum estradiol levels, indicating that testosterone's effects on hypothalamic factors might be induced by its androgenic activity. These findings suggest that as well as estrogen, androgens have negative feedback effects on GnRH in females and that the underlying mechanisms responsible for these effects are similar, but do not completely correspond, to the mechanisms underlying the effects of estrogen on GnRH.  (日)    [継承]
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誌名 (必須): Gynecological Endocrinology (International Society of Gynecological Endocrinology)
(pISSN: 0951-3590, eISSN: 1473-0766)

ISSN (任意): 1473-0766
ISSN: 0951-3590 (pISSN: 0951-3590, eISSN: 1473-0766)
Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Title(ISO): Gynecol Endocrinol
Publisher: Taylor & Francis
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 34 [継承]
(必須): 5 [継承]
(必須): 437 441 [継承]
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年月日 (必須): 西暦 2018年 5月 29日 (平成 30年 5月 29日) [継承]
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DOI (任意): 10.1080/09513590.2017.1409709    (→Scopusで検索) [継承]
PMID (任意): 29187003    (→Scopusで検索) [継承]
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機関リポジトリ : 112451 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1080/09513590.2017.1409709  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: NKB  (日)    [継承]
4.(英) KeywordList.Keyword: RFRP  (日)    [継承]
5.(英) KeywordList.Keyword: Testosterone  (日)    [継承]
6.(英) KeywordList.Keyword: dynorphin  (日)    [継承]
7.(英) KeywordList.Keyword: kisspeptin  (日)    [継承]

標準的な表示

和文冊子 ● Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Rie Yanagihara, Yiliyasi Mayila and Minoru Irahara : The effects of chronic testosterone administration on hypothalamic gonadotropin-releasing hormone regulatory factors (Kiss1, NKB, pDyn and RFRP) and their receptors in female rats., Gynecological Endocrinology, Vol.34, No.5, 437-441, 2018.
欧文冊子 ● Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Rie Yanagihara, Yiliyasi Mayila and Minoru Irahara : The effects of chronic testosterone administration on hypothalamic gonadotropin-releasing hormone regulatory factors (Kiss1, NKB, pDyn and RFRP) and their receptors in female rats., Gynecological Endocrinology, Vol.34, No.5, 437-441, 2018.

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