| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
| [継承] |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Tomida Chisato (日) 冨田 知里 (読) とみだ ちさと
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 2. | (英) Yamagishi Naoko (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Nagano Hikaru (日) 永野 ひかる (読) ながの ひかる
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 4. | 内田 貴之 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | 真板 綾子
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Hirasaka Katsuya (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 二川 健 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | 近藤 茂忠
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Antiangiogenic agent sunitinib induces epithelial to mesenchymal transition and accelerates motility of colorectal cancer cells. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Although vascular endothelial growth factor receptor (VEGF-R)-targeted antiangiogenic agents are important treatment for a number of human malignancies, there is accumulating evidence that the therapies may promote disease progression, such as invasion and metastasis. How tumors become to promote their evasiveness remains fully uncertain. One of possible mechanisms for the adaptation may be a direct effect of VEGF-R inhibitors on tumor cells expressing VEGF-R. To elucidate a direct effect of VEGF-R-targeting drug (sunitinib), we established a human colorectal cancer cell model adapted to sunitinib. The sunitinib-conditioned cells showed a significant increase in cellular motility and migration activities, compared to the vehicle-treated control cells. Consistent with the phenotype, the sunitinib-conditioned cells decreased the expression levels of E-cadherin (an epithelial marker), while significantly increased the levels of Slug and Zeb1 (mesenchymal markers). Expression profiles of VEGF-R in the sunitinib-conditioned cells showed that only neuropilin-1 (NRP1) expression was significantly increased among all VEGF-R tested. Blockade of NRP1 using its antagonist clearly repressed the migration activation in sunitinib-conditioned cells, but not in the control cells. These results suggest that inhibition of VEGF-R on colorectal cancer cells can drive the epithelial-mesenchymal transition, leading to activation of cell motility in an NRP1-dependent manner. J. Med. Invest. 64: 250-254, August, 2017. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Angiogenesis Inhibitors (日) (読)
| [継承] |
| 2. | (英) Cell Movement (日) (読)
| [継承] |
| 3. | (英) Colorectal Neoplasms (日) (読)
| [継承] |
| 4. | (英) Epithelial-Mesenchymal Transition (日) (読)
| [継承] |
| 5. | (英) HCT116 Cells (日) (読)
| [継承] |
| 6. | (英) Humans (日) (読)
| [継承] |
| 7. | (英) Indoles (日) (読)
| [継承] |
| 8. | (英) Neuropilin-1 (日) (読)
| [継承] |
| 9. | (英) Pyrroles (日) (読)
| [継承] |
| 10. | (英) Receptors, Vascular Endothelial Growth Factor (日) (読)
| [継承] |
| 11. | (英) Transcriptome (日) (読)
| [継承] |
| ○発行所 (推奨): | □ | (英) The University of Tokushima Faculty of Medicine (日) 国立大学法人 徳島大学医学部 (読)
| [継承] |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 64
| [継承] |
| ○号 (必須): | □ | 3-4
| [継承] |
| ○頁 (必須): | □ | 250 254
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 0月 初日 (平成 29年 0月 初日)
| [継承] |
| ○URL (任意): | □ | http://repo.lib.tokushima-u.ac.jp/111126
| [継承] |
| ○DOI (任意): | □ | 10.2152/jmi.64.250 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 28954991 (→Scopusで検索)
| [継承] |
| ○CRID (任意): | □ | 1390001204247522048
| [継承] |
| ○NAID : | □ | 130006105181
| [継承] |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-85030217718
| [継承] |
| ○機関リポジトリ : | □ | 111126
| [継承] |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): | 1. | 二川 健 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
| [継承] |
| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.2152/jmi.64.250 (日)
| [継承] |
| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 3. | (英) KeywordList.Keyword: VEGF receptor tyrosine kinase inhibitor (日)
| [継承] |
| 4. | (英) KeywordList.Keyword: evasive adaptation (日)
| [継承] |
| 5. | (英) KeywordList.Keyword: sunitinib (日)
| [継承] |