| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 駒 貴明 ([徳島大学.大学院医歯薬学研究部.医学域.先端医学教育研究プロジェクト]/[徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.微生物病原学])
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| 2. | (英) Veljkovic Veljko (日) (読)
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| 3. | (英) Anderson Danielle E (日) (読)
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| 4. | (英) Wang Lin-Fa (日) (読)
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| 5. | (英) Rossi Shannan L (日) (読)
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| 6. | (英) Shan Chao (日) (読)
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| 7. | (英) Shi Pei-Yong (日) (読)
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| 8. | (英) Beasley David W (日) (読)
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| 9. | (英) Bukreyeva Natalya (日) (読)
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| 10. | (英) Smith Jeanon N (日) (読)
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| 11. | (英) Hallam Steven (日) (読)
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| 12. | (英) Huang Cheng (日) (読)
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| 13. | (英) von Messling Veronika (日) (読)
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| 14. | (英) Paessler Slobodan (日) (読)
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| ○題名 (必須): | □ | (英) Zika virus infection elicits auto-antibodies to C1q. (日)
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| ○要約 (任意): | □ | (英) Zika virus (ZIKV) causes mostly asymptomatic infection or mild febrile illness. However, with an increasing number of patients, various clinical features such as microcephaly, Guillain-Barré syndrome and thrombocytopenia have also been reported. To determine which host factors are related to pathogenesis, the E protein of ZIKV was analyzed with the Informational Spectrum Method, which identifies common information encoded by primary structures of the virus and the respective host protein. The data showed that the ZIKV E protein and the complement component C1q cross-spectra are characterized by a single dominant peak at the frequency F=0.338, suggesting similar biological properties. Indeed, C1q-specific antibodies were detected in sera obtained from mice and monkeys infected with ZIKV. As C1q has been known to be involved not only in immunity, but also in synaptic organization and different autoimmune diseases, a ZIKV-induced anti-C1q antibody response may contribute to the neurological complications. These findings might also be exploited for the design of safe and efficacious vaccines in the future. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Scientific Reports ([Nature Publishing Group])
(eISSN: 2045-2322)
| ○ISSN (任意): | □ | 2045-2322
ISSN: 2045-2322
(eISSN: 2045-2322) Title: Scientific reportsTitle(ISO): Sci RepPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 8
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| ○号 (必須): | □ | 1
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| ○頁 (必須): |
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| ○年月日 (必須): | □ | 西暦 2018年 1月 30日 (平成 30年 1月 30日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/s41598-018-20185-8 (→Scopusで検索)
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| ○PMID (任意): | □ | 29382894 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 112405
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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