| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○著者 (必須): | 1. | 毛利 安宏 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生命科学])
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| 2. | (英) Ueda Yoshihiro (日) (読)
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| 3. | (英) Yamano Tomoyoshi (日) (読)
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| 4. | (英) Matsumoto Minoru (日) 松本 穣 (読) まつもと みのる
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| ○学籍番号 (推奨): | □ | ****
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| 5. | 常山 幸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.疾患病理学])
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| 6. | (英) Kinashi Tatsuo (日) (読)
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| 7. | 松本 満
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| ○題名 (必須): | □ | (英) Mode of tolerance induction and requirement for Aire are governed by the cell types that express self-antigen and those that present antigen (日)
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| ○要約 (任意): | □ | (英) Aire controls the fate of autoreactive thymocytes (i.e., clonal deletion or development into regulatory T cells [Tregs]) through transcriptional control of the expression of tissue-restricted self-antigens (TRAs) from medullary thymic epithelial cells (mTECs) and bone marrow (BM)-derived cells. Although TRAs expressed by mTECs and BM-derived cells are suggested to complement each other to generate a full spectrum of TRAs, little is known about the relative contribution of TRAs from each component for establishment of self-tolerance. Furthermore, the precise role of Aire in specific types of Aire-expressing APCs remains elusive. We have approached these issues by generating two different types of transgenic mouse (Tg) model, which express a prefixed model self-antigen driven by the insulin promoter or the Aire promoter. In the insulin-promoter Tg model, mTECs alone were insufficient for clonal deletion, and BM-derived APCs were required for this action by utilizing Ag transferred from mTECs. In contrast, mTECs alone were able to induce Tregs, although at a much lower efficiency in the absence of BM-derived APCs. Importantly, lack of Aire in mTECs, but not in BM-derived APCs, impaired both clonal deletion and production of Tregs. In the Aire-promoter Tg model, both mTECs and BM-derived APCs could independently induce clonal deletion without Aire, and production of Tregs was impaired by the lack of Aire in mTECs, but not in BM-derived APCs. These results suggest that the fate of autoreactive thymocytes together with the requirement for Aire depend on the cell types that express self-antigens and the types of APCs involved in tolerance induction. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigen Presentation (日) (読)
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| 3. | (英) Antigen-Presenting Cells (日) (読)
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| 4. | (英) Autoantigens (日) (読)
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| 5. | (英) Clonal Deletion (日) (読)
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| 6. | (英) Epithelial Cells (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Gene Expression Regulation (日) (読)
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| 9. | (英) Gene Knock-In Techniques (日) (読)
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| 10. | (英) Genes, Synthetic (日) (読)
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| 11. | インスリン (insulin)
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| 12. | (英) Male (日) (読)
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| 13. | (英) Mice (日) (読)
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| 14. | (英) Mice, Inbred C57BL (日) (読)
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| 15. | ノックアウトマウス (knockout mice)
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| 16. | (英) Mice, Transgenic (日) (読)
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| 17. | (英) Ovalbumin (日) (読)
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| 18. | (英) Promoter Regions, Genetic (日) (読)
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| 19. | (英) Rats (日) (読)
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| 20. | (英) Specific Pathogen-Free Organisms (日) (読)
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| 21. | (英) T-Lymphocytes, Regulatory (日) (読)
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| 22. | (英) Thymus Gland (日) (読)
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| 23. | (英) Transcription Factors (日) (読)
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| 24. | (英) Transgenes (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
| ○ISSN (任意): | □ | 0022-1767
ISSN: 0022-1767
(pISSN: 0022-1767, eISSN: 1550-6606) Title: Journal of immunology (Baltimore, Md. : 1950)Title(ISO): J ImmunolPublisher: Oxford University Press (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 199
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| ○号 (必須): | □ | 12
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| ○頁 (必須): | □ | 3959 3971
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 11月 3日 (平成 29年 11月 3日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.4049/jimmunol.1700892 (→Scopusで検索)
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| ○PMID (任意): | □ | 29101311 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-85038566360
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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