| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○著者 (必須): | 1. | 佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
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| 2. | (英) Hasegawa Chise (日) 長谷川 知世 (読) はせがわ ちせ
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| ○学籍番号 (推奨): | □ | ****
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| 3. | 田嶋 敦
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| 4. | (英) Nozawa Shiari (日) (読)
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| 5. | (英) Yoshiike Miki (日) (読)
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| 6. | (英) Koh Eitetsue (日) (読)
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| 7. | (英) Kanaya Jiro (日) (読)
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| 8. | (英) Namiki Mikio (日) (読)
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| 9. | (英) Matsumiya Kiyomi (日) (読)
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| 10. | (英) Tsujimura Akira (日) (読)
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| 11. | (英) Komatsu Kiyoshi (日) (読)
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| 12. | (英) Itoh Naoki (日) (読)
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| 13. | (英) Eguchi Jiro (日) (読)
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| 14. | 山内 あい子
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| 15. | (英) Iwamoto Teruaki (日) (読)
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| ○題名 (必須): | □ | (英) Association of TUSC1 and DPF3 gene polymorphisms with male infertility (日)
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| ○要約 (任意): | □ | (英) Recently, genome-wide association studies of a Hutterite population in the USA revealed that five single nucleotide polymorphisms (SNPs) with a significant association with sperm quality and/or function in ethnically diverse men from Chicago were significantly correlated with family size. Of these, three SNPs (rs7867029, rs7174015, and rs12870438) were found to be significantly associated with the risk of azoospermia and/or oligozoospermia in a Japanese population. In this study, we investigated whether the rs10966811 (located in an intergenic region between the TUSC1 and IZUMO3 genes) and rs10129954 (located in the DPF3 gene) SNPs, previously related to family size, are associated with male infertility. In addition, we performed association analysis between rs12348 in TUSC1 and rs2772579 in IZUMO3 and male infertility. We genotyped 145 patients with infertility (including 83 patients with azoospermia and 62 with oligozoospermia) and 713 fertile controls by PCR-RFLP technique for polymorphism. Because rs10966811 has no restriction sites, the SNP rs12376894 with strong linkage disequilibrium was selected as an alternative to rs10966811. There was a statistically significant association between rs12376894 proxy SNP of rs10966811 and oligozoospermia. Also, a statistically significant association between rs10129954 and azoospermia, and oligozoospermia was observed. When we assessed the relationship between rs12348 in TUSC1 and rs2772579 in IZUMO3 and male infertility traits, we found that rs12348 in TUSC1 was significantly associated with azoospermia and oligozoospermia, but rs2772579 in IZUMO3 was not associated with male infertility. We found that the polymorphisms in TUSC1 and DPF3 displayed strong associations with male infertility. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Journal of Assisted Reproduction and Genetics (International Working Group on Preimplantation Genetics)
(pISSN: 1058-0468, eISSN: 1573-7330)
| ○ISSN (任意): | □ | 1573-7330
ISSN: 1058-0468
(pISSN: 1058-0468, eISSN: 1573-7330) Title: Journal of assisted reproduction and geneticsTitle(ISO): J Assist Reprod GenetSupplier: Kluwer OnlinePublisher: Springer (NLM Catalog)
(Scopus)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 35
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 257 263
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 2月 初日 (平成 30年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s10815-017-1052-x (→Scopusで検索)
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| ○PMID (任意): | □ | 28975488 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s10815-017-1052-x (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Azoospermia (日)
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| 4. | (英) KeywordList.Keyword: Double plant homeodomain fingers (日)
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| 5. | (英) KeywordList.Keyword: Family 3 (日)
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| 6. | (英) KeywordList.Keyword: Male infertility (日)
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| 7. | (英) KeywordList.Keyword: Oligozoospermia (日)
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| 8. | (英) KeywordList.Keyword: Single nucleotide polymorphism (日)
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| 9. | (英) KeywordList.Keyword: Tumor suppressor candidate 1 (日)
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