| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 教育
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| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): | □ | 博士前期課程学生による研究報告
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| ○組織 (推奨): | 1. | 徳島大学.総合科学教育部.地域科学専攻.環境共生分野 (2009年4月1日〜)
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| 2. | 徳島大学.生物資源産業学部.生物資源産業学科.食料科学コース (2016年4月1日〜)
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| ○著者 (必須): | 1. | (英) Ikeda Mizuki (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 2. | (英) Deguchi Junji (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
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| 3. | (英) Fukushima Shota (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
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| [継承] |
| 4. | (英) Qingyu Ai (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): | □ | ****
| [ユーザ] |
| [継承] |
| 5. | (英) Katayama Norihiro (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 6. | 三浦 哉 ([徳島大学.大学院社会産業理工学研究部.社会総合科学域.人間科学系.スポーツ健康分野]/[徳島大学.総合科学部.社会総合科学科.心身健康コース])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 7. | 小山 保夫
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Some adverse actions of chlorothalonil at sublethal levels in rat thymic lymphocytes: Its relation to Zn2+ (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Chlorothalonil, a polychlorinated aromatic fungicide, is considered non-toxic to small mammals. However, chlorothalonil inactivates sulfhydryl enzymes and depletes cellular glutathione. Chlorothalonil increases intracellular Zn2+ concentration ([Zn2+]i) in mammalian cells possibly because intracellular Zn2+ is released via zinc-thiol/disulfide interchange. The effects of chlorothalonil at sublethal concentrations on the cellular content of nonprotein thiols ([NPT]i) and [Zn2+]i were examined using flow cytometry in rat thymocytes. Low concentrations (0.3 1 µM) of chlorothalonil increased, but high concentrations (3 10 µM) decreased [NPT]i. These effects of chlorothalonil were partly attenuated by an intracellular Zn2+ chelator. Chlorothalonil at 0.3 10 µM increased [Zn2+]i in a concentration-dependent manner, which was largely dependent on the release of intracellular Zn2+. Both the decrease in [NPT]i and increase in [Zn2+]i increase the vulnerability of cells to oxidative stress. Chlorothalonil at 1 10 µM potentiated the cytotoxicity of H2O2 (300 µM). It was also the case for 10 µM pentachloronitrobenzene, but not 10 µM pentachlorophenol. In conclusion, chlorothalonil at low (sublethal) micromolar concentrations is cytotoxic to mammalian cells under oxidative stress. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cell Survival (日) (読)
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| 3. | (英) Fungicides, Industrial (日) (読)
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| 4. | (英) Hydrogen Peroxide (日) (読)
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| 5. | (英) Male (日) (読)
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| 6. | (英) Nitriles (日) (読)
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| 7. | (英) Rats, Wistar (日) (読)
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| 8. | (英) Thymocytes (日) (読)
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| 9. | (英) Zinc (日) (読)
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| ○発行所 (推奨): | □ | Elsevier Science
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| ○誌名 (必須): | □ | Environmental Toxicology and Pharmacology (European Journal of Pharmacology: Environmental Toxicology and Pharmacology)
(pISSN: 1382-6689, eISSN: 1872-7077)
| ○ISSN (任意): | □ | 1872-7077
ISSN: 1382-6689
(pISSN: 1382-6689, eISSN: 1872-7077) Title: Environmental toxicology and pharmacologyTitle(ISO): Environ Toxicol PharmacolPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 59
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 61 65
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 4月 末日 (平成 30年 4月 末日)
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| ○URL (任意): | □ | https://www.sciencedirect.com/science/article/pii/S1382668918300413
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| ○DOI (任意): | □ | 10.1016/j.etap.2018.03.006 (→Scopusで検索)
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| ○PMID (任意): | □ | 29544185 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○機関リポジトリ : | □ | 111987
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| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.ELocationID: S1382-6689(18)30041-3 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.etap.2018.03.006 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Chlorothalonil (日)
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| 5. | (英) KeywordList.Keyword: Cytotoxicity (日)
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| 6. | (英) KeywordList.Keyword: Intracellular Zn(2+) (日)
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| 7. | (英) KeywordList.Keyword: Lymphocyte (日)
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| 8. | (英) KeywordList.Keyword: Nonprotein thiol (日)
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