『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=336704EID:336704, Map:0, LastModified:2019年3月2日(土) 20:40:35, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[青田 桂子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.青田 桂子 ([徳島大学.病院.診療科.歯科口腔外科.口腔内科])
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2.山ノ井 朋子
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3.可児 耕一 ([徳島大学.病院.診療科.歯科口腔外科.口腔内科])
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4.東 雅之 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔内科学]/[徳島大学.病院.診療科.歯科口腔外科.口腔内科])
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題名 (必須): (英) Cepharanthine inhibits IFN--induced CXCL10 by suppressing the JAK2/STAT1 signal pathway in human salivary gland ductal cells  (日)    [継承]
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要約 (任意): (英) Cepharanthine, a biscolaurine alkaloid isolated from the plant Stephania cephalantha Hayata, has been reported to have potent anti-inflammatory properties. Here, we investigated the effects of cepharanthine on the expression of CXCL10 (a CXC chemokine induced by interferon-gamma [IFN-γ] that has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions) in IFN-γ-treated human salivary gland cell lines. We observed that IFN-γ-induced CXCL10 production in NS-SV-DC cells (a human salivary gland ductal cell line), but not in NS-SV-AC cells (a human salivary gland acinar cell line). Cepharanthine inhibited the IFN-γ-induced CXCL10 production in NS-SV-DC cells. A Western blot analysis showed that cepharanthine prevented the phosphorylation of JAK2 and STAT1, but did not interfere with the NF-κB pathway. Moreover, cepharanthine inhibited the IFN-γ-mediated chemotaxis of Jurkat T cells. These results suggest that cepharanthine suppresses IFN-γ-induced CXCL10 production via the inhibition of the JAK2/STAT1 signaling pathway in human salivary gland ductal cells. Our findings also indicate that cepharanthine could inhibit the chemotaxis of Jurkat T cells by reducing CXCL10 production.  (日)    [継承]
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誌名 (必須): Inflammation ([Springer-Verlag])
(pISSN: 0360-3997, eISSN: 1573-2576)

ISSN (任意): 1573-2576
ISSN: 0360-3997 (pISSN: 0360-3997, eISSN: 1573-2576)
Title: Inflammation
Title(ISO): Inflammation
Supplier: Kluwer Online
Publisher: Springer US
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 41 [継承]
(必須): 1 [継承]
(必須): 50 58 [継承]
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年月日 (必須): 西暦 2018年 2月 初日 (平成 30年 2月 初日) [継承]
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DOI (任意): 10.1007/s10753-017-0662-x    (→Scopusで検索) [継承]
PMID (任意): 28879548    (→Scopusで検索) [継承]
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機関リポジトリ : 112922 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1007/s10753-017-0662-x  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) KeywordList.Keyword: CXCL10  (日)    [継承]
4.(英) KeywordList.Keyword: IFN-γ  (日)    [継承]
5.(英) KeywordList.Keyword: JAK/STAT1 signaling  (日)    [継承]
6.(英) KeywordList.Keyword: cepharanthine  (日)    [継承]
7.(英) KeywordList.Keyword: primary Sjögren's syndrome  (日)    [継承]
8.(英) KeywordList.Keyword: salivary gland ductal cells  (日)    [継承]

標準的な表示

和文冊子 ● Keiko Aota, Tomoko Yamanoi, Kohichi Kani and Masayuki Azuma : Cepharanthine inhibits IFN--induced CXCL10 by suppressing the JAK2/STAT1 signal pathway in human salivary gland ductal cells, Inflammation, Vol.41, No.1, 50-58, 2018.
欧文冊子 ● Keiko Aota, Tomoko Yamanoi, Kohichi Kani and Masayuki Azuma : Cepharanthine inhibits IFN--induced CXCL10 by suppressing the JAK2/STAT1 signal pathway in human salivary gland ductal cells, Inflammation, Vol.41, No.1, 50-58, 2018.

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