| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○著者 (必須): | 1. | 青田 桂子 ([徳島大学.病院.診療科.歯科口腔外科.口腔内科])
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| 2. | 山ノ井 朋子
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| 3. | 可児 耕一 ([徳島大学.病院.診療科.歯科口腔外科.口腔内科])
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| 4. | 東 雅之
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| ○題名 (必須): | □ | (英) Cepharanthine inhibits IFN--induced CXCL10 by suppressing the JAK2/STAT1 signal pathway in human salivary gland ductal cells (日)
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| ○要約 (任意): | □ | (英) Cepharanthine, a biscolaurine alkaloid isolated from the plant Stephania cephalantha Hayata, has been reported to have potent anti-inflammatory properties. Here, we investigated the effects of cepharanthine on the expression of CXCL10 (a CXC chemokine induced by interferon-gamma [IFN-γ] that has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions) in IFN-γ-treated human salivary gland cell lines. We observed that IFN-γ-induced CXCL10 production in NS-SV-DC cells (a human salivary gland ductal cell line), but not in NS-SV-AC cells (a human salivary gland acinar cell line). Cepharanthine inhibited the IFN-γ-induced CXCL10 production in NS-SV-DC cells. A Western blot analysis showed that cepharanthine prevented the phosphorylation of JAK2 and STAT1, but did not interfere with the NF-κB pathway. Moreover, cepharanthine inhibited the IFN-γ-mediated chemotaxis of Jurkat T cells. These results suggest that cepharanthine suppresses IFN-γ-induced CXCL10 production via the inhibition of the JAK2/STAT1 signaling pathway in human salivary gland ductal cells. Our findings also indicate that cepharanthine could inhibit the chemotaxis of Jurkat T cells by reducing CXCL10 production. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Inflammation ([Springer-Verlag])
(pISSN: 0360-3997, eISSN: 1573-2576)
| ○ISSN (任意): | □ | 1573-2576
ISSN: 0360-3997
(pISSN: 0360-3997, eISSN: 1573-2576) Title: InflammationTitle(ISO): InflammationSupplier: Kluwer OnlinePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 41
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 50 58
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 2月 初日 (平成 30年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s10753-017-0662-x (→Scopusで検索)
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| ○PMID (任意): | □ | 28879548 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 112922
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s10753-017-0662-x (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: CXCL10 (日)
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| 4. | (英) KeywordList.Keyword: IFN-γ (日)
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| 5. | (英) KeywordList.Keyword: JAK/STAT1 signaling (日)
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| 6. | (英) KeywordList.Keyword: cepharanthine (日)
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| 7. | (英) KeywordList.Keyword: primary Sjögren's syndrome (日)
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| 8. | (英) KeywordList.Keyword: salivary gland ductal cells (日)
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