| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国際共著 (徳島大学内研究者と国外研究機関所属研究者との共同研究)
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sato Miyuki (日) (読)
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| 2. | (英) Sato Katsuya (日) (読)
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| 3. | (英) Tomura Kotone (日) (読)
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| 4. | 小迫 英尊 ([徳島大学.先端酵素学研究所.基幹研究部門])
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| 5. | (英) Sato Ken (日) (読)
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| ○題名 (必須): | □ | (英) The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) In Caenorhabditis elegans embryos, paternally provided organelles, including mitochondria, are eliminated by a process of selective autophagy called allophagy, the mechanism by which mitochondrial DNA is inherited maternally. However, it remains unclear how paternal organelles are recognized and targeted for autophagy. Here, we identified an autophagy receptor for allophagy, ALLO-1. ALLO-1 is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. After fertilization, ALLO-1 accumulates on the paternal organelles before autophagosome formation, and this localization depends on the ubiquitin modification of the paternal organelles. We also identified IKKE-1, a worm homologue of the TBK1 and IKKϵ family kinase, as another critical regulator of allophagy. IKKE-1 interacts with ALLO-1, and the IKKE-1-dependent phosphorylation of ALLO-1 is important for paternal organelle clearance. Thus, we propose that ALLO-1 is the allophagy receptor whose function is regulated by IKKE-1-dependent phosphorylation. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Nature Cell Biology ([Nature Publishing Group])
(pISSN: 1465-7392, eISSN: 1476-4679)
| ○ISSN (任意): | □ | 1476-4679
ISSN: 1465-7392
(pISSN: 1465-7392, eISSN: 1476-4679) Title: Nature cell biologyTitle(ISO): Nat Cell BiolPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 20
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 81 91
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2018年 1月 20日 (平成 30年 1月 20日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/s41556-017-0008-9 (→Scopusで検索)
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| ○PMID (任意): | □ | 29255173 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-85038407524
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1038/s41556-017-0008-9 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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