| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Sasai Miwa (日) (読)
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| 2. | (英) Sakaguchi Naoya (日) (読)
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| 3. | (英) Ma Ji Su (日) (読)
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| 4. | (英) Nakamura Shuhei (日) (読)
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| 5. | (英) Kawabata Tsuyoshi (日) (読)
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| 6. | (英) Bando Hironori (日) (読)
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| 7. | (英) Lee Youngae (日) (読)
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| 8. | 齊藤 達哉
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| 9. | (英) Akira Shizuo (日) (読)
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| 10. | (英) Iwasaki Akiko (日) (読)
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| 11. | (英) Standley Daron M (日) (読)
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| 12. | (英) Yoshimori Tamotsu (日) (読)
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| 13. | (英) Yamamoto Masahiro (日) (読)
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| ○題名 (必須): | □ | (英) Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense. (日)
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| ○要約 (任意): | □ | (英) Mammalian autophagy-related 8 (Atg8) homologs consist of LC3 proteins and GABARAPs, all of which are known to be involved in canonical autophagy. In contrast, the roles of Atg8 homologs in noncanonical autophagic processes are not fully understood. Here we show a unique role of GABARAPs, in particular gamma-aminobutyric acid (GABA)-A-receptor-associated protein-like 2 (Gabarapl2; also known as Gate-16), in interferon- (IFN-)-mediated antimicrobial responses. Cells that lacked GABARAPs but not LC3 proteins and mice that lacked Gate-16 alone were defective in the IFN--induced clearance of vacuolar pathogens such as Toxoplasma. Gate-16 but not LC3b specifically associated with the small GTPase ADP-ribosylation factor 1 (Arf1) to mediate uniform distribution of interferon-inducible GTPases. The lack of GABARAPs reduced Arf1 activation, which led to formation of interferon-inducible GTPase-containing aggregates and hampered recruitment of interferon-inducible GTPases to vacuolar pathogens. Thus, GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases. (日)
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| ○キーワード (推奨): | 1. | (英) ADP-Ribosylation Factor 1 (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Autophagy (日) (読)
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| 4. | (英) CRISPR-Cas Systems (日) (読)
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| 5. | (英) Carrier Proteins (日) (読)
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| 6. | (英) Computer Simulation (日) (読)
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| 7. | (英) Cytoskeletal Proteins (日) (読)
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| 8. | (英) Enzyme-Linked Immunosorbent Assay (日) (読)
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| 9. | (英) Flow Cytometry (日) (読)
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| 10. | (英) Fluorescent Antibody Technique (日) (読)
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| 11. | (英) GTP Phosphohydrolases (日) (読)
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| 12. | (英) Gene Editing (日) (読)
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| 13. | (英) Immunoblotting (日) (読)
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| 14. | (英) Immunoprecipitation (日) (読)
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| 15. | (英) Interferon-gamma (日) (読)
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| 16. | (英) Membrane Proteins (日) (読)
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| 17. | (英) Mice (日) (読)
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| 18. | (英) Microtubule-Associated Proteins (日) (読)
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| 19. | (英) Toxoplasma (日) (読)
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| 20. | (英) Toxoplasmosis (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Nature Immunology ([Nature Publishing Group])
(pISSN: 1529-2908, eISSN: 1529-2916)
| ○ISSN (任意): | □ | 1529-2916
ISSN: 1529-2908
(pISSN: 1529-2908, eISSN: 1529-2916) Title: Nature immunologyTitle(ISO): Nat ImmunolPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login])
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| ○巻 (必須): | □ | 18
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| ○号 (必須): | □ | 8
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| ○頁 (必須): | □ | 899 910
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 6月 12日 (平成 29年 6月 12日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/ni.3767 (→Scopusで検索)
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| ○PMID (任意): | □ | 28604719 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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