| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Minisola Salvatore (日) (読)
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| 2. | (英) Peacock Munro (日) (読)
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| ○学籍番号 (推奨): |
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| 3. | 福本 誠二
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| ○学籍番号 (推奨): |
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| 4. | (英) Cipriani Cristiana (日) (読)
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| ○貢献度 (任意): |
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| 5. | (英) Pepe Jessica (日) (読)
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| 6. | (英) Tella Sri Harsha (日) (読)
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| 7. | (英) Collins Michael T (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Tuour-induced osteomalacia (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Tumour-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a rare paraneoplastic disorder caused by tumours that secrete fibroblast growth factor 23 (FGF23). Owing to the role of FGF23 in renal phosphate handling and vitamin D synthesis, TIO is characterized by decreased renal tubular reabsorption of phosphate, by hypophosphataemia and by low levels of active vitamin D. Chronic hypophosphataemia ultimately results in osteomalacia (that is, inadequate bone mineralization). The diagnosis of TIO is usually suspected when serum phosphate levels are chronically low in the setting of bone pain, fragility fractures and muscle weakness. Locating the offending tumour can be very difficult, as the tumour is often very small and can be anywhere in the body. Surgical removal of the tumour is the only definitive treatment. When the tumour cannot be located or when complete resection is not possible, medical treatment with phosphate salts or active vitamin D is necessary. One of the most promising emerging treatments for unresectable tumours that cause TIO is the anti-FGF23 monoclonal antibody KRN23. The recent identification of a fusion of fibronectin and fibroblast growth factor receptor 1 (FGFR1) as a molecular driver in some tumours not only sheds light on the pathophysiology of TIO but also opens the door to a better understanding of the transcription, translocation, post-translational modification and secretion of FGF23, as well as suggesting approaches to targeted therapy. Further study will reveal if the FGFR1 pathway is also involved in tumours that do not harbour the translocation. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Aged, 80 and over (日) (読)
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| 4. | (英) Antibodies, Monoclonal (日) (読)
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| 5. | (英) Bone and Bones (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Fibroblast Growth Factors (日) (読)
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| 8. | (英) Fibronectins (日) (読)
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| 9. | (英) Fractures, Bone (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Hypophosphatemia (日) (読)
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| 12. | (英) Japan (日) (読)
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| 13. | (英) Male (日) (読)
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| 14. | (英) Middle Aged (日) (読)
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| 15. | (英) Muscle Weakness (日) (読)
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| 16. | (英) Neoplasms, Connective Tissue (日) (読)
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| 17. | (英) Osteomalacia (日) (読)
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| 18. | (英) Pain (日) (読)
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| 19. | (英) Paraneoplastic Syndromes (日) (読)
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| 20. | (英) Phosphates (日) (読)
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| 21. | (英) Protein Processing, Post-Translational (日) (読)
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| 22. | (英) Receptor, Fibroblast Growth Factor, Type 1 (日) (読)
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| 23. | (英) Vitamin D (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Nature Reviews. Disease Primers ([Nature Publishing Group])
(eISSN: 2056-676X)
| ○ISSN (任意): | □ | 2056-676X
ISSN: 2056-676X
(eISSN: 2056-676X) Title: Nature reviews. Disease primersTitle(ISO): Nat Rev Dis PrimersPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 3
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 17004 17004
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 7月 13日 (平成 29年 7月 13日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/nrdp.2017.44 (→Scopusで検索)
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| ○PMID (任意): | □ | 28703220 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1038/nrdp.2017.44 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Review (日)
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| 4. | (英) SupplMeshList.SupplMeshName: Oncogenic osteomalacia (日)
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