『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=334850)

EID=334850EID:334850, Map:0, LastModified:2018年3月5日(月) 11:06:49, Operator:[成石 浩司], Avail:TRUE, Censor:0, Owner:[成石 浩司], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.美原(和田) 智恵 ([徳島大学.病院.中央診療施設等.総合歯科診療部])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.瀬戸 浩行
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Ohba Hirofumi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Tokunaga Kaku (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.木戸 淳一 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.永田 俊彦
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.成石 浩司 ([徳島大学.病院.診療科.歯科.歯周病科(第二保存科)])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Local administration of calcitonin inhibits alveolar bone loss in an experimental periodontitis in rats.  (日)    [継承]
副題 (任意):
要約 (任意): (英)   (日) Calcitonin (CTN), a calcium regulatory hormone, promotes calcium diuresis from the kidney and suppresses bone resorption. The objective of this study was to evaluate whether the topical and intermittent application of CTN inhibits alveolar bone resorption using ligature-induced experimental periodontitis in rats. Experimental periodontitis was induced by placing a nylon ligature around maxillary molars of 8-week-old male Wistar rats for 20 days. Thirty-two rats were divided into four groups: basal sham control group, periodontitis group, periodontitis plus 0.2 U CTN (low dose), and periodontitis plus 1.0 U CTN (high dose) group. To investigate the effects of CTN on alveolar bone resorption, CTN was topically injected into the palatal gingivae every 2 days after ligature removal (day 0). Micro-computed tomography (CT) analysis was performed for linear parameter assessment of alveolar bone on day 5 and day 14. Periodontal tissues were examined histo-pathologically to assess the differences among the study groups. Micro-CT images showed that alveolar bone resorption was induced statistically around the molar of ligatured rats on day 5 and day 14. The amount of bone resorption was more severe on day 14 than that on day 5. On day 5, only high-dose CTN treatment significantly suppressed bone resorption. In addition, both doses of CTN significantly suppressed bone resorption on day 14. Histological examination clarified that there were fewer TRAP-positive cells in the CTN treatment groups than in the periodontitis group on day 5. Local administration of CTN decreased alveolar bone resorption by regulating osteoclast activation in rats with periodontitis.   [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): Biomedicine & Pharmacotherapy (Elsevier Masson SAS)
(pISSN: 0753-3322, eISSN: 1950-6007)

ISSN (任意): 1950-6007
ISSN: 0753-3322 (pISSN: 0753-3322, eISSN: 1950-6007)
Title: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Title(ISO): Biomed Pharmacother
Publisher: Elsevier Masson
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 97 [継承]
(必須): 1 [継承]
(必須): 765 770 [継承]
都市 (任意):
年月日 (必須): 西暦 2018年 1月 3日 (平成 30年 1月 3日) [継承]
URL (任意):
DOI (任意): 10.1016/j.biopha.2017.10.165    (→Scopusで検索) [継承]
PMID (任意): 29107933    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Chie Wada -Mihara, Hiroyuki Seto, Hirofumi Ohba, Kaku Tokunaga, Jun-ichi Kido, Toshihiko Nagata and Koji Naruishi : Local administration of calcitonin inhibits alveolar bone loss in an experimental periodontitis in rats., Biomedicine & Pharmacotherapy, Vol.97, No.1, 765-770, 2018.
欧文冊子 ● Chie Wada -Mihara, Hiroyuki Seto, Hirofumi Ohba, Kaku Tokunaga, Jun-ichi Kido, Toshihiko Nagata and Koji Naruishi : Local administration of calcitonin inhibits alveolar bone loss in an experimental periodontitis in rats., Biomedicine & Pharmacotherapy, Vol.97, No.1, 765-770, 2018.

関連情報

Number of session users = 0, LA = 0.70, Max(EID) = 382774, Max(EOID) = 1022369.