| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Hana Taijun (日) (読)
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| 2. | (英) Tanaka Shota (日) (読)
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| 3. | (英) Nakatomi Hirofumi (日) (読)
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| 4. | (英) Shojima Masaaki (日) (読)
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| 5. | 福本 誠二
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| 6. | (英) Ikemura Masako (日) (読)
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| 7. | (英) Saito Nobuhito (日) (読)
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| ○題名 (必須): | □ | (英) Definitive surgical treatment of osteomalacia induced by skull base tumor and determination of the half-life of serum fibroblast growth factor 23. (日)
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| ○要約 (任意): | □ | (英) Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome often associated with fibroblast growth factor 23 (FGF23)-producing tumors such as phosphaturic mesenchymal tumor, mixed connective tissue variant (PMTMCT) affecting the bone and soft tissue. We experienced a patient with progressive bone and muscle pain due to FGF23-related TIO. Venous sampling had strongly suggested the anterior skull base as a source of FGF23, which led to the discovery of a small tumor in the ethmoid sinus extending intracranially. Radical surgical resection confirmed the histological diagnosis of PMTMCT with FGF23 immunopositivity and achieved durable tumor control with complete resolution of symptoms. We serially measured serum FGF23 level before, during and after surgery and analyzed the data to determine the half-life of FGF23. Serum FGF23 level sharply declined as early as 20 minutes after en bloc tumor resection and completely normalized after surgery. The half-life of FGF23 was calculated to be approximately 18.5 minutes using single phase exponential decay model as well as semilog transformation formula. Serial measurements of serum FGF23 level can potentially declare "complete" resection of a FGF23-producing tumor and total cure of TIO; in this regard, development of its intraoperative measurement would be helpful in the management of this endocrine tumor. (日)
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| ○キーワード (推奨): |
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| ○誌名 (必須): | □ | Endocrine Journal ([社団法人 日本内分泌学会])
(pISSN: 0918-8959, eISSN: 1348-4540)
| ○ISSN (任意): | □ | 1348-4540
ISSN: 0918-8959
(pISSN: 0918-8959, eISSN: 1348-4540) Title: Endocrine journalTitle(ISO): Endocr JSupplier: 一般社団法人 日本内分泌学会Publisher: Japan Endocrine Society (NLM Catalog)
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| ○巻 (必須): | □ | 64
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| ○号 (必須): | □ | 10
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| ○頁 (必須): | □ | 1033 1039
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 8月 2日 (平成 29年 8月 2日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1507/endocrj.EJ17-0177 (→Scopusで検索)
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| ○PMID (任意): | □ | 28768937 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1507/endocrj.EJ17-0177 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) KeywordList.Keyword: Fibroblast growth factor 23 (日)
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| 4. | (英) KeywordList.Keyword: Half-Life (日)
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| 5. | (英) KeywordList.Keyword: Intraoperative measurement (日)
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| 6. | (英) KeywordList.Keyword: Phosphaturic mesenchymal tumor (日)
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| 7. | (英) KeywordList.Keyword: Tumor induced osteomalacia (日)
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