| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): | □ | 国内共著 (徳島大学内研究者と国内(学外)研究者との共同研究 (国外研究者を含まない))
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 髙濵 充寛
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| 2. | (英) Mitsunori Fukuda (日) (読)
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| 3. | (英) Norihiko Ohbayashi (日) (読)
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| 4. | (英) Tatsuya Kozaki (日) (読)
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| 5. | (英) Takuma Misawa (日) (読)
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| 6. | (英) Toru Okamoto (日) (読)
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| 7. | (英) Yoshiharu Matsuura (日) (読)
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| 8. | (英) Shizuo Akira (日) (読)
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| 9. | 齊藤 達哉
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| ○題名 (必須): | □ | (英) The RAB2B-GARIL5 complex promotes cytosolic DNA-induced innate immune responses (日)
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| ○要約 (任意): | □ | (英) Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces the IFN antiviral response. However, the regulatory mechanisms that mediate cGAS-triggered signaling have not been fully explored. Here, we show the involvement of a small GTPase, RAB2B, and its effector protein, Golgi-associated RAB2B interactor-like 5 (GARIL5), in the cGAS-mediated IFN response. RAB2B-deficiency affects the IFN response induced by cytosolic DNA. Consistent with this, RAB2B deficiency enhances replication of vaccinia virus, a DNA virus. After DNA stimulation, RAB2B colocalizes with stimulator of interferon genes (STING), the downstream signal mediator of cGAS, on the Golgi apparatus. The GTP-binding activity of RAB2B is required for its localization on the Golgi apparatus and for recruitment of GARIL5. GARIL5 deficiency also affects the IFN response induced by cytosolic DNA and enhances replication of vaccinia virus. These findings indicate that the RAB2B-GARIL5 complex promotes IFN responses against DNA viruses by regulating the cGAS-STING signaling axis. (日)
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| ○キーワード (推奨): |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Cell Reports (Cell Press)
(pISSN: 2639-1856, eISSN: 2211-1247)
| ○ISSN (任意): | □ | 2211-1247
ISSN: 2639-1856
(pISSN: 2639-1856, eISSN: 2211-1247) Title: Cell reportsTitle(ISO): Cell RepPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 20
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| ○号 (必須): | □ | 12
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| ○頁 (必須): | □ | 2944 2954
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2017年 9月 19日 (平成 29年 9月 19日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.celrep.2017.08.085 (→Scopusで検索)
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| ○PMID (任意): | □ | 28930687 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-85029588290
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| ○備考 (任意): | 1. | (英) Article.ELocationID: S2211-1247(17)31227-5 (日)
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| 2. | (英) Article.ELocationID: 10.1016/j.celrep.2017.08.085 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Rab GTPase (日)
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| 5. | (英) KeywordList.Keyword: antiviral response (日)
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| 6. | (英) KeywordList.Keyword: host defense (日)
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| 7. | (英) KeywordList.Keyword: innate immunity (日)
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| 8. | (英) KeywordList.Keyword: interferon (日)
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| 9. | (英) KeywordList.Keyword: organelle (日)
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