『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=331561)

EID=331561EID:331561, Map:0, LastModified:2018年4月25日(水) 17:06:46, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[西田 憲生], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Saijo Saki (日) 西條 早希 (読) さいじょう さき
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学籍番号 (推奨): **** [ユーザ]
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2.桑野 由紀 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.病態生理学])
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3.増田 清士
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4.西川 達哉
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5.六反 一仁
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6.西田 憲生 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.病態生理学])
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題名 (必須): (英) Serine/arginine-rich splicing factor 7 regulates p21-dependent growth arrest in colon cancer cells.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Serine/arginine-rich splicing factors (SRSFs) play wide-ranging roles in gene expression through post-transcriptional regulation as well as pre-mRNA splicing. SRSF7 was highly expressed in colon cancer tissues, and its knockdown inhibited cell growth in colon cancer cells (HCT116) in association with altered expression of 4,499 genes. The Ingenuity Pathway Analysis revealed that cell cycle-related canonical pathways were ranked as the highly enriched category in the affected genes. Western blotting confirmed that p21, a master regulator in cell cycle, was increased without any induction of p53 in SRSF7 knockdown cells. Furthermore, cyclin-dependent kinase 2 and retinoblastoma protein were remained in the hypophosphorylated state. In addition, the SRSF7 knockdown-induced cell growth inhibition was observed in p53-null HCT116 cells, suggesting that p53-independent pathways were involved in the SRSF7 knockdown-induced cell growth inhibition. The reduction of SRSF7 stabilized cyclin-dependent kinase inhibitor 1A (CDKN1A) mRNA without any activation of the CDKN1A promoter. Interestingly, SRSF7 knockdown also blocked p21 degradation. These results suggest that the reduction of SRSF7 post-transcriptionally regulates p21 induction at the multistep processes. Thus, the present findings disclose a novel, important role of SRSF7 in cell proliferation through regulating p21 levels. J. Med. Invest. 63: 219-226, August, 2016.  (日)    [継承]
キーワード (推奨): 1. (英) Cell Proliferation (日) (読) [継承]
2. (英) Colonic Neoplasms (日) (読) [継承]
3. (英) Cyclin-Dependent Kinase Inhibitor p21 (日) (読) [継承]
4. (英) HCT116 Cells (日) (読) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) RNA, Messenger (日) (読) [継承]
7. (英) Serine-Arginine Splicing Factors (日) (読) [継承]
8. (英) Tumor Suppressor Protein p53 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1349-6867
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J. Med. Invest.
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
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年月日 (必須): 西暦 2016年 0月 初日 (平成 28年 0月 初日) [継承]
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DOI (任意): 10.2152/jmi.63.219    (→Scopusで検索) [継承]
PMID (任意): 27644562    (→Scopusで検索) [継承]
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機関リポジトリ : 110162 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.2152/jmi.63.219  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Saki Saijo, Yuki Kuwano, Kiyoshi Masuda, Tatsuya Nishikawa, Kazuhito Rokutan and Kensei Nishida : Serine/arginine-rich splicing factor 7 regulates p21-dependent growth arrest in colon cancer cells., The Journal of Medical Investigation : JMI, Vol.63, No.3-4, 219-226, 2016.
欧文冊子 ● Saki Saijo, Yuki Kuwano, Kiyoshi Masuda, Tatsuya Nishikawa, Kazuhito Rokutan and Kensei Nishida : Serine/arginine-rich splicing factor 7 regulates p21-dependent growth arrest in colon cancer cells., The Journal of Medical Investigation : JMI, Vol.63, No.3-4, 219-226, 2016.

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