| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 木村 哲夫
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| 2. | 宮本 弘志 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.消化器内科学]/[徳島大学.病院.診療科.内科.消化器内科])
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| 3. | (英) Fukuya Akira (日) (読)
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| 4. | 北村 晋志
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| 5. | 岡本 耕一 ([徳島大学.病院.診療科.内科.消化器内科])
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| 6. | 木村 雅子 (->個人[梶 雅子])
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| 7. | 六車 直樹
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| 8. | 池本 哲也 ([徳島大学.病院.中央診療施設等.安全管理部]/[徳島大学.病院.診療科.外科.消化器・移植外科])
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| 9. | 島田 光生
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| 10. | 米田 亜樹子
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| 11. | 坂東 良美 ([徳島大学.病院.診療科.病理診断科])
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| 12. | (英) Takishita Makoto (日) (読)
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| 13. | 高山 哲治
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| ○題名 (必須): | □ | (英) Neuroendocrine carcinoma of the pancreas with similar genetic alterations to invasive ductal adenocarcinoma. (日)
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| ○要約 (任意): | □ | (英) Neuroendocrine carcinoma (NEC) of the pancreas is very rare, and its origin is not fully elucidated. Here, we present a case of a small-size NEC of the pancreas that is genetically similar to invasive ductal adenocarcinoma (IDA). A 65-year-old man was referred to our hospital due to obstructive jaundice and found to have a 12-mm solid tumor in the pancreas head. The tumor exhibited low vascularity on enhanced computed tomography, and endoscopic retrograde pancreatographic imaging revealed an irregular obstruction in a branch duct of the pancreas. The patient was thereby diagnosed with a pancreatic ductal cancer, and stomach-preserving pancreaticoduodenectomy with regional lymph node resection was performed. Histochemical analysis of the resected tumor showed that the neoplastic cells with scanty cytoplasm and hyperchromatic nuclei strongly expressed chromogranin A and synaptophysin. The Ki-67 index was 40 % in the most proliferative tumor regions, and the tumor was diagnosed as a NEC of the pancreas. However, in the analysis of genetic alterations of the tumor tissue, the neoplastic cells showed altered KRAS, TP53, and SMAD4/DPC4, suggesting that the NEC in our case is genetically related to IDA. Our data suggest that poorly differentiated IDAs may transform into NECs. (日)
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| ○キーワード (推奨): | 1. | (英) Aged (日) (読)
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| 2. | (英) Carcinoma, Neuroendocrine (日) (読)
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| 3. | (英) Carcinoma, Pancreatic Ductal (日) (読)
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| 4. | (英) Cholangiopancreatography, Endoscopic Retrograde (日) (読)
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| 5. | (英) Disease Progression (日) (読)
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| 6. | (英) Genes, p53 (日) (読)
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| 7. | (英) Humans (日) (読)
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| 8. | (英) Male (日) (読)
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| 9. | (英) Mutation (日) (読)
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| 10. | (英) Pancreatic Neoplasms (日) (読)
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| 11. | (英) Proto-Oncogene Proteins p21(ras) (日) (読)
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| 12. | (英) Smad4 Protein (日) (読)
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| 13. | (英) Tomography, X-Ray Computed (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Clinical Journal of Gastroenterology ([財団法人 日本消化器病学会])
(pISSN: 1865-7257, eISSN: 1865-7265)
| ○ISSN (任意): | □ | 1865-7265
ISSN: 1865-7257
(pISSN: 1865-7257, eISSN: 1865-7265) Title: Clinical journal of gastroenterologyTitle(ISO): Clin J GastroenterolPublisher: Springer (NLM Catalog)
(医中誌Web)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 9
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 261 265
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 8月 初日 (平成 28年 8月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s12328-016-0655-6 (→Scopusで検索)
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| ○PMID (任意): | □ | 27262570 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1007/s12328-016-0655-6 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Case Reports (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: KRAS (日)
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| 5. | (英) KeywordList.Keyword: Neuroendocrine carcinoma (日)
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| 6. | (英) KeywordList.Keyword: Pancreatic cancer (日)
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| 7. | (英) KeywordList.Keyword: SMAD4 (日)
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| 8. | (英) KeywordList.Keyword: p53 (日)
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