| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○学究種別 (推奨): |
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| ○著者 (必須): | 1. | 向井 理恵 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野])
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| 2. | (英) Horikawa Hitomi (日) (読)
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| 3. | (英) Lin Pei-Yi (日) (読)
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| 4. | (英) Tsukumo Nao (日) (読)
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| 5. | 二川 健 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.生体栄養学])
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| 6. | (英) Kawamura Tomoyuki (日) (読)
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| 7. | 根本 尚夫
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| 8. | 寺尾 純二
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| ○題名 (必須): | □ | (英) 8-Prenylnaringenin promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice. (日)
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| ○要約 (任意): | □ | (英) 8-Prenylnaringenin (8-PN) is a prenylflavonoid that originates from hop extracts and is thought to help prevent disuse muscle atrophy. We hypothesized that 8-PN affects muscle plasticity by promoting muscle recovery under disuse muscle atrophy. To test the promoting effect of 8-PN on muscle recovery, we administered an 8-PN mixed diet to mice that had been immobilized with a cast to one leg for 14 days. Intake of the 8-PN mixed diet accelerated recovery from muscle atrophy, and prevented reductions in Akt phosphorylation. Studies on cell cultures of mouse myotubes in vitro demonstrated that 8-PN activated the PI3K/Akt/P70S6K1 pathway at physiological concentrations. A cell-culture study using an inhibitor of estrogen receptors and an in vivo experiment with ovariectomized mice suggested that the estrogenic activity of 8-PN contributed to recovery from disuse muscle atrophy through activation of an Akt phosphorylation pathway. These data strongly suggest that 8-PN is a naturally occurring compound that could be used as a nutritional supplement to aid recovery from disuse muscle atrophy. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cell Line (日) (読)
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| 3. | (英) Enzyme Activation (日) (読)
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| 4. | (英) Flavanones (日) (読)
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| 5. | (英) Hindlimb Suspension (日) (読)
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| 6. | (英) Male (日) (読)
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| 7. | (英) Mice (日) (読)
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| 8. | (英) Mice, Inbred C57BL (日) (読)
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| 9. | (英) Muscle Proteins (日) (読)
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| 10. | (英) Muscle, Skeletal (日) (読)
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| 11. | (英) Muscular Atrophy (日) (読)
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| 12. | (英) Oncogene Protein v-akt (日) (読)
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| 13. | リン酸化 (phosphorylation)
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| 14. | (英) Phytoestrogens (日) (読)
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| 15. | (英) Protein Biosynthesis (日) (読)
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| 16. | (英) Recovery of Function (日) (読)
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| 17. | シグナル伝達 (signal transduction)
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| 18. | (英) Treatment Outcome (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | American Journal of Physiology. Regulatory, Integrative and Comparative Physiology ([アメリカ生理学会])
(pISSN: 0363-6119, eISSN: 1522-1490)
| ○ISSN (任意): | □ | 1522-1490
ISSN: 0363-6119
(pISSN: 0363-6119, eISSN: 1522-1490) Title: American journal of physiology. Regulatory, integrative and comparative physiologyTitle(ISO): Am J Physiol Regul Integr Comp PhysiolPublisher: American Physiological Society (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 311
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| ○号 (必須): | □ | 6
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| ○頁 (必須): | □ | R1022 R1031
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 9月 14日 (平成 28年 9月 14日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1152/ajpregu.00521.2015 (→Scopusで検索)
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| ○PMID (任意): | □ | 27629889 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 112458
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| ○備考 (任意): | 1. | (英) PublicationType: Journal Article (日)
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