| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 木下 貴正
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| 2. | 三田村 佳典 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.眼科学])
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| 3. | (英) Mori Terumi (日) (読)
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| 4. | (英) Akaiwa Kei (日) (読)
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| 5. | 仙波 賢太郎
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| 6. | 江川 麻理子 ([徳島大学.病院.診療科.感覚·皮膚·運動機能科.眼科])
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| 7. | (英) Mori Junya (日) (読)
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| 8. | (英) Sonoda Shozo (日) (読)
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| 9. | (英) Sakamoto Taiji (日) (読)
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| ○題名 (必須): | □ | (英) Changes in choroidal structures in eyes with chronic central serous chorioretinopathy after half-dose photodynamic therapy (日)
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| ○要約 (任意): | □ | (英) To determine the structural changes in the choroid after half-dose photodynamic therapy (hPDT) in eyes with chronic central serous chorioretinopathy (CSC). This was a retrospective interventional study of 29 eyes of 29 patients who underwent hPDT for chronic CSC with serous retinal detachment (SRD) and were followed for ≥3 months. Enhanced depth imaging optical coherence tomographic (EDI-OCT) images of the subfoveal choroid were converted to binary images. The central choroidal thickness (CCT), the cross sectional subfoveal choroidal area, the hyporeflective and hyperreflective areas of the inner, outer, and whole choroid were determined at the baseline, and at 1, 3, and 12 months after the hPDT. The SRDs were resolved in 26 (89.7%) eyes at 3 months after the hPDT. The mean CCT (P = 0.001), the total choroidal area (P = 0.001), and the hypo-reflective area (P = 0.003) of the whole choroid were significantly decreased from the baseline at 3 months. The hyperreflective area of whole choroid was not significantly changed during the study period (P = 0.083). The hyperreflective but not the hyporeflective area of the inner choroid was significantly decreased at 3 months (P = 0.001, P = 1.000, respectively). The hyporeflective but not the hyperreflective area of the outer choroid was significantly decreased at 3 months (P = 0.001, P = 1.000, respectively). The hyperreflective area of the inner choroid and hyporeflective area of the outer choroid were significantly decreased after hPDT for chronic CSC. Because the hyperreflective and hyporeflective area correspond to the choroidal stroma and vessels, respectively, the decreased CCT and subfoveal choroidal area after hPDT may be attributed to a decrease in the exudative changes in the inner choroidal stroma and the reduction of the dilation of the outer choroidal vessels. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Aged, 80 and over (日) (読)
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| 4. | (英) Central Serous Chorioretinopathy (日) (読)
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| 5. | (英) Choroid (日) (読)
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| 6. | (英) Chronic Disease (日) (読)
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| 7. | (英) Female (日) (読)
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| 8. | (英) Fluorescein Angiography (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) Indocyanine Green (日) (読)
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| 11. | (英) Male (日) (読)
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| 12. | (英) Middle Aged (日) (読)
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| 13. | (英) Photochemotherapy (日) (読)
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| 14. | (英) Tomography, Optical Coherence (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | PLoS ONE (Public Library of Science)
(eISSN: 1932-6203)
| ○ISSN (任意): | □ | 1932-6203
ISSN: 1932-6203
(eISSN: 1932-6203) Title: PloS oneTitle(ISO): PLoS OnePublisher: PLOS (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | e0163104 e0163104
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 9月 16日 (平成 28年 9月 16日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1371/journal.pone.0163104 (→Scopusで検索)
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| ○PMID (任意): | □ | 27636093 (→Scopusで検索)
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| ○機関リポジトリ : | □ | 112333
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1371/journal.pone.0163104 (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC5026334 (日)
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| 4. | (英) CoiStatement: The authors have declared that no competing interests exist. (日)
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