| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): | □ | 研究
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 佐光 亘
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| 2. | 阿部 考志
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| 3. | (英) Murakami Nagahisa (日) (読)
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| 4. | 宮﨑 由道
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| 5. | 和泉 唯信 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.臨床神経科学]/[徳島大学.病院.診療科.内科.脳神経内科])
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| 6. | 原田 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.放射線医学])
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| 7. | 梶 龍兒 ([徳島大学.研究支援・産官学連携センター])
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| ○題名 (必須): | □ | (英) Imaging-based differential diagnosis between multiple system atrophy and Parkinson's disease. (日)
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| ○要約 (任意): | □ | (英) There are many tools for differentiating between multiple system atrophy with predominant parkinsonian features (MSA-P) and Parkinson's disease (PD). These include middle cerebellar peduncle (MCP) width, apparent diffusion coefficient (ADC) value of the putamen and cerebellum, and (123)I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy images. We aimed to directly compare the above-mentioned methods, and to determine the optimal tool for differential diagnosis. Eleven patients with MSA-P and 36 patients with PD were enrolled. Of these, 7 patients with MSA-P and 14 patients with PD were chosen as background-matched subjects. We measured MCP width, ADC value of the putamen and cerebellum, and MIBG myocardial scintigraphy images. Area under curve (AUC) of receiver operating characteristic (ROC) was assessed to compare the above-mentioned methods. MCP width and ADC value of the putamen may be helpful for differentiating between MSA-P and PD relative to other methods in background-matched patients (MCP, AUC=0.95; putamen ADC, AUC=0.88; cerebellar ADC, AUC=0.70; MIBG, AUC=0.78). Similar AUCs were seen in all patients with different backgrounds. Our findings suggested that MCP width and ADC value of the putamen could be superior to ADC value of the cerebellum and MIBG uptake for differentiating between MSA-P and PD. (日)
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| ○キーワード (推奨): | 1. | (英) Area Under Curve (日) (読)
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| 2. | 小脳 (cerebellum)
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| 3. | (英) Diagnosis, Differential (日) (読)
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| 4. | (英) Female (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Male (日) (読)
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| 7. | (英) Middle Aged (日) (読)
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| 8. | (英) Middle Cerebellar Peduncle (日) (読)
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| 9. | (英) Multiple System Atrophy (日) (読)
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| 10. | パーキンソン病 (Parkinson's disease)
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| 11. | (英) Putamen (日) (読)
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| 12. | (英) ROC Curve (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of the Neurological Sciences (World Federation of Neurology)
(pISSN: 0022-510X, eISSN: 1878-5883)
| ○ISSN (任意): | □ | 1878-5883
ISSN: 0022-510X
(pISSN: 0022-510X, eISSN: 1878-5883) Title: Journal of the neurological sciencesTitle(ISO): J Neurol SciPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 368
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 104 108
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2016年 6月 29日 (平成 28年 6月 29日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.jns.2016.06.061 (→Scopusで検索)
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| ○PMID (任意): | □ | 27538610 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-84978114190
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| ○備考 (任意): | 1. | (英) Article.ELocationID: 10.1016/j.jns.2016.06.061 (日)
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| 2. | (英) Article.ELocationID: S0022-510X(16)30392-6 (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) KeywordList.Keyword: Cerebellum (日)
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| 5. | (英) KeywordList.Keyword: MIBG (日)
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| 6. | (英) KeywordList.Keyword: Magnetic resonance imaging (日)
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| 7. | (英) KeywordList.Keyword: Middle cerebellar peduncle (日)
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| 8. | (英) KeywordList.Keyword: Multiple system atrophy (日)
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| 9. | (英) KeywordList.Keyword: Parkinson's disease (日)
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| 10. | (英) KeywordList.Keyword: Putamen (日)
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